After a series of unsolved brutal murders, New York City Detective Vic Deleo finds himself in a routine instigation in Manhattan that leads to an encounter with an enigmatic woman, Cassandra, who extracts Vic's true inner power, showing him hat he is actually much more than human. Disappearing, she leaves him with a burning desire to find out more about her and his new powers. With his newly attained knowledge and powers, Vic joins forces with a small crew of supernatural misfits which includes the unlikely couple, Solana & Cheveyo, who travel across the globe in an attempt to stop the Antediluvians- the 3rd generation of Vampires- from plotting biblical world domination