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Brain Targeted Drug Delivery Systems: A Focus on Nanotechnology and Nanoparticulates

Editat de Huile Gao, Xiaoling Gao
Notă GoodReads:
en Limba Engleză Carte Paperback – 26 Sep 2018

Brain Targeted Drug Delivery Systems: A Focus on Nanotechnology and Nanoparticulates provides a guide on nanoparticulates to both academic and industry researchers. The book discusses key points in the development of brain targeted drug delivery, summarizes available strategies, and considers the main problems and pitfalls evidenced in current studies on brain targeted drug delivery systems. As the brain is the most important organ in the human body, and disorders of the central nervous system (CNS) are the most serious threat to human life, this book highlights advances and new research in drug delivery methods to the brain.

 

 

 

  • Provides an overview of brain targeting drug delivery that is useful to both academic and industry-based researchers
  • Discusses key points in developing brain targeting drug delivery systems
  • Summarizes and presents currently available strategies for brain targeting drug delivery
  • Covers not only current studies and their strengths, but also gives insight into the pitfalls of current research

 

 

 

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Specificații

ISBN-13: 9780128140017
ISBN-10: 0128140011
Pagini: 499
Dimensiuni: 191 x 235 mm
Greutate: 0.81 kg
Editura: ELSEVIER SCIENCE

Public țintă

Pharmaceutical industry scientists, graduate students and academic researchers in pharmaceutical science and materials science working in drug delivery and nanotechnology, clinical researchers including neuroscientists and cancer researchers

Cuprins

1. Introduction and overview
Part I Physiology and principles for brain targeting drug delivery
2. Anatomy and physiology of blood-brain barrier
3. Recent progress in blood-brain barrier transportation research
4. In vitro and in vivo models of BBB to evaluate brain targeting drug delivery
Part II Nanoparticles-based brain targeting delivery strategies
5. Receptor-mediated transportation through BBB
6. Carrier-mediated transportation through BBB
7. Brain drug delivery by adsorption-mediated transcytosis
8. Efflux pump inhibition to enhance brain targeting delivery
9. Physically open BBB
10. Nanoparticle systems for nose-to-brain delivery
11. Brain local delivery strategy
Part III Nanoparticles-based brain targeting delivery for CNS disorder management
12.Glioma targeted delivery systems
13.Nanotherapeutic strategies for the treatment of neurodegenerative diseases
14. Savaging brain ischemia by increasing brain uptake of neuroprotectants
Part IV Perspective and pitfalls of nanoparticles-based brain targeting delivery
15. Neurotoxicity concern about the brain targeting delivery systems
16. The intra-brain distribution of brain targeting delivery systems
17. The elimination of brain-targeted nanomaterials
18. Perspective on brain targeting drug delivery systems