Jessie Hightower, a former African American marine, is doing his best to move forward with his life in Philadelphia when he sees a news broadcast about the recent disappearance of thousands of men and women nationwide. Despite launching an intense investigation, authorities at several government agencies have no idea what happened to them. A few days later, the reasons why become evident when the sky explodes in light and alien spacecrafts emerge from the clouds. Aliens have finally answered the call sent from Earth. As they emerge from their craft, problems arise. They are unfriendly, want to inhabit the planet, and intend to rid Earth of all humans through a lethal virus they let fall like snowflakes. Moments later, they head back to their craft and disappear into the clouds. As the death count rapidly rises, Earth's inhabitants become desperate for answers. When Jessie and the rest of his black brothers and sisters discover they are immune to the virus, they realize they are the only ones capable of saving the human population from extinction. When the aliens eventually return to Earth, will they find more death and destruction or a human population determined to beat the odds?