Bioenergetics and Thermodynamics: Model Systems: Synthetic and Natural Chelates and Macrocycles as Models for Biological and Pharmaceutical Studies: Nato Science Series C:, cartea 55

Bioenergetics and Thermodynamics. Aims and Methodology of the School.- Design of Peptide Molecules to Mimic the Metal Binding Sites of Proteins.- Calorimetry and Biology.- Bioinorganic Chemistry of Nickel.- Design and Synthesis of Ligands.- Holes, Handedness, Handles, and Hopes: Meeting the Requirements of Primary Binding, Chirality, Secondary Interactions and Functionality in Enzyme Analogues.- Testing of Ligands.- Calorimetric Techniques to Study Proton-Ligand and Metal-Ligand Interactions.- Structural and Energetic Aspects of Metal-Ligand Binding.- Transport of Metal Ions by Liquid Membranes Containing Macrocyclic Carriers.- Enthalpy, Free-Energy, and Entropy Data for Structure-Activity Relationships in Acids and Bases.- Potentiometric and Spectroscopic Determination of Equilibrium Constants.- Experimental Data in Chemical and Biological Systems at Equilibrium.- What Concentration Scale? What Standard State? What Species are Present?.- Treatment and Analysis of Equilibrium Data by Computers.- Mixed Complexes.- Kinetics and Thermodynamics of Enzyme Action and Regulation.- Computer Models of Biological Systems.- Membranes, Alkali Metals and Transfer.- Synthetic Solvent-Polymeric Membranes and Their Transport Characteristics.- Macrocycles and Cation Selectivity.- Selectivity of Membranes Towards Ions and Molecules.- Transport Phenomena across Solid and Liquid Membranes.- Carriers and Channels in Artificial and Biological Membranes.- Lipid Bilayer Electrochemistry and -Role of the Carriers.- The Lipid Bilayer: A Model System for Biological Membranes.- Differential Scanning Calorimetry. Processes Involving Proteins.- Recent Advances in Biochemical Calorimetry.- Interpretation of Calorimetric Data from Cooperative Systems.- Selective Complexation of Ammonium and Guanidinium Salts by Synthetic Receptor Molecules.- Dynamical Aspects of Small-Molecule Protein Interaction.- Molecular Receptors, Carriers and Catalysts: Design, Scope and Prospects.- Metal Ions in Biological Systems.- Metal Ion — Protein Interactions in Solutions.- Final Comments.- Contributing authors.