Vivian, Wendy, Kate and Lucy take the party to New Orleans for their third girls getaway and Wendy's last hurrah before she's hitched. Their French Quarter nights are full of beads, boas, bachelorette kisses and big-ass beers. Things veer off course when new friend Daisy becomes the third exotic dancer to disappear from the Crescent City in a month. Hunky Detective Antonio Robichaux and his by-the-book partner, Eddie Leffall, are on the case, and they want the girls to stay out of it. Old friends Al and Adrienne Russo help the girls chase down bad guys in historic streetcars, airborne airboats and a commandeered carriage, culminating in a chaotic chase for the kidnapper. The Getaway Girlz go beyond Bourbon Street and risk their own safety to help solve the not-so-easy case in the Big Easy.