Atopic dermatitis is a chronic inflammatory skin disease that is characterized by xerosis, eczema lesions with skin barrier defects, and severe itch. This compilation describes recent advances in our understanding of intractable itch mechanisms and the development of antipruritic therapies in in this condition. Additionally, the authors summarize the current developments in understanding the comorbidities of atopic dermatitis. Insight into various emerging therapies along with currently approved treatments is provided. Some proposed interventions are presented regarding the population group that can benefit the most according to the severity of the symptoms, the mechanism of action of the intervention and the possible adverse effects. The authors use Pentaherbs Formula to educate to readers on efforts in Traditional Chinese Medicine research to adopt this historic and unique complementary medicine as a safer and scientific-based therapy for atopic dermatitis. In closing, Atopic Dermatitis: From Diagnosis to Treatment focuses on topical corticosteroids that are commonly used by dermatologists and general physicians to treat selected difficult dermatoses effectively.