Atherosclerosis III: Proceedings of the Third International Symposium

I. The Arterial Wall in the Pathogenesis of Atherosclerosis.- Workshop: The Composition of Early Lesions.- The Lesion.- Metabolism of the Arterial Wall.- Biophysical Factors in Vascular Structure and Caliber.- Contraction of Endothelial Cells as a Key Mechanism in Atherogenesis and Treatment of Atherosclerosis with Endothelial Cell Relaxants.- II. Lipoproteins and Proteins of the Arterial Wall.- Uptake of Intact Plasma Lipoproteins into the Arterial Wall of the Rabbit.- Beta-Lipoprotein Entry into the Arterial Wall and its Prevention.- Identification of Lipoproteins Involved in Human Atherosclerosis.- Quantitative Interrelationships Between Plasma Constituents and Normal and Atherosclerotic Human Intimai Tissue.- III. Lipids of the Arterial Wall.- Lipid Metabolic Pool in Subcellular Fractions of Rabbit and Human Atherosclerotic Lesions.- Glucose and Lipid Metabolism in the Human Arteriosclerotic Aorta.- Cholesterol Transfer in Vitro Between the Rabbit Aorta and Serum Lipoproteins.- Arterial Lipid Metabolism in Diabetic Animal Models with Reduced or Elevated Plasma Insulin Levels.- Lipid Metabolism in Perfused Human Coronary Arteries and Saphenous Veins.- IV. Enzymes of the Arterial Wall.- Workshop: Arterial Wall Enzymes.- A Comparison of the Rates of Lipolysis and Lipogenesis in the Rat Aorta.- Properties and Positional Specificity of Lipases in the Human Aorta.- The Influence of Atherosclerosis on Cholesterol Esterifying Activity of Rabbit and Monkey Aorta.- Aortic Uptake of Chylomicron Triglyceride in Vivo and Aortic Lipoprotein Triglyceride Lipase in Rat.- V. Metabolic Functions of the Arterial Cell.- Workshop: Metabolism and Function of Arterial Cells in Culture.- Cell Proliferation and Ultrastructural Changes in Regressing Atheroslerotic Lesions After Reduction of Serum Cholesterol.- Glucosamineglycans in Cell Membranes and the Extracellular Compartment of the Arterial Wall.- Increased Mitotic Activity in Primary Cultures of Aortic Medial Smooth muscle Cells After Exposure to Hyperlipemic Serum.- The Synthesis and Secretion of Sulfated Glycosaminoglycans by Vascular Smooth Muscle Cells In Vitro.- Etiology of Myointimal Cell Proliferation.- VI. Permeability of the Arterial Wall and Connective Tissue Reactions.- Workshop: Factors Affecting Permeability and Connective Tissue Reactions in Atherosclerosis.- Association of Coronary Artery Endothelial Injury with Elevation of Serum Bile Acids in the Rat.- Effect of Nicotine on Severity of Acute Myocardial Ischemic Injury.- Endothelial Permeability: Focal and Regional Patterns of 131I-Albumin and 131I-Fibrinogen Uptake and Transmural Distribution in the Pig Aorta.- Increased Collagen Synthesis in Early Rabbit Atherosclerosis and its Inhibition by Cis-Hydroxyproline.- Basement Membranes in Muscle Capillaries of Patients with Hyperlipidemias.- Effect of Adrenocortical Hormones on the Integrity of Rat Aortic Endothelium.- VII. Platelets-Thrombogenesis-Fibrinogen-Fibrinolysis.- Thrombosis and Atherosclerosis.- The Natural History of Experimentally Induced Mural Thrombi in Systemic Arteries of Normocholesterolaemic and Hypercholesterolaemic Monkeys.- Behavior of Fibrinogen and Fibrinolysis in Type II and Type IV Hyperlipemic Subjects and in Patients with Coronary Heart Disease.- Control of Platelet Function in Postmyocardial Infarction Patients During a Two Year Aspirin Study.- Dietary Fat, Platelet Function and Coronary Heart Disease in Man.- Enhanced Platelet Aggregation as a Risk Factor for Thromboembolic Complications in Atherosclerosis.- VIII. Animal Models of Atherosclerosis.- Workshop: Animal Models of Atherosclerosis.- Animal Models of Atherosclerosis and/or Myocardial Infarction.- Differences Between Human and Animal Atherosclerosis.- Experimental Atherosclerosis Due to Ascorbic Acid Deficiency.- On Pathogenetic Factors Concerned with Vascular Lesions Induced by High Sucrose Diet in Monkeys.- Ultrastructural Changes in the Coronary Arteries of Primates (Macaca Iris) after a Prolonged, Mild Carbon Monoxide Exposure.- Responses of Two Macaque Species to Atherogenic Diet and its Withdrawal.- Preliminary Results of Reversibility of Spontaneous and Diet-Induced Atherosclerosis in Squirrel Monkeys by Chondroitin-4-Sulfate.- Necrogenic Agent Obtained from Cholesterol Used in Dietary Experiments.- Production of Advanced Atheromatous Lesions in an Allografted Segment of Aorta in a Normocholesterolaemic Rabbit.- Rat Homografts of Arterial Wall Fragments: A Contribution to the Understanding of Experimental Atherosclerosis.- Morphologic and Histochemical Studies on Human and Minipig Arteries.- Effect of Exercise on Collagen and Elastin in Aortas of Cockerels with Induced Atherosclerosis.- The Role of Hypertension and Hyperlipemia in the Morphogenesis of Experimental Atherosclerosis.- IX. Liproprotein and Lipid Metabolism in Experimental Animals.- Workshop: Lipid Metabolism in Primates.- Uptake and Autoradiographic Localization of Very Low Density Lipoproteins in Rat Liver.- Characterization of Experimental Type II Hyperlipoproteinaemia in Guinea Pigs.- Cholesteryl Ester Accumulation in Rat Hepatoma Tissue Culture Cells.- Effects of Dietary Protein on Plasma Cholesterol Levels in Rabbits Fed Cholesterol-Free Semisynthetic Diets.- X. Hyperlipoproteinemia and Lipoprotein Disorders — Genetics and Epidemiology.- Workshop: Types and Genetics of Hyperlipoproteinemias.- Genetics and Atherosclerosis.- Pediatric Aspects of Atherosclerosis.- Heritability of Serum Lipids and Lipoproteins.- The Inheritance of Lipoprotein Disorders and the Risks of Coronary Death in First-Degree Relatives of 193 Survivors of Myocardial Infarction.- Hyperlipidemia in Survivors of Myocardial Infarction: Relationship Between Genetic Classification and Lipoprotein Phenotype.- Quantitative Genetic Studies of the Human Plasma Lp(a) Lipoprotein.- Coronary Artery Disease Risk in Familial Type II Hyperlipoproteinemia.- Prospective Study of Cord Blood Cholesterol to Predict Level of Cholesterol and Type II Hyperlipoproteinemia in Adolescence.- Detection of Familial Hyperlipoproteinemia by Cord Blood Analysis.- Pre-Beta1-Lipoprotein: Relationship to Angiographically Proven Coronary Heart Disease and to Lp(a) Lipoprotein.- Prevalence and Distribution of Femoral Atheromas in Human Hyperlipoproteinemia, Type II and IV.- Primary Hyperlipoproteinemias and Other Risk Factors in Patients with Occlusive Arterial Disease of the Lower Limb.- Atherosclerotic Lesions of the Cerebral Arteries in Young Persons.- XI. Plasma Lipids.- Cholesterol and Triglyceride Metabolism.- Workshop: Cholesterol and Triglyceride Metabolism in Man.- Metabolic Studies in Hyperlipidaemia.- Correlation of Kinetic Parameters of Cholesterol Metabolism with Serum Cholesterol Levels.- The Relationship of Esterification of Plasma Cholesterol to Hypertriglyceridemia.- Role of a Lipid Carrier Protein in the Control of Lipid Synthesis, Metabolism, and Transport.- Fatty Acids.- Impaired Fatty Acid Incorporation into Adipose Tissue (FIAT) in Hypertriglyceridemia. Effect of Intravenous Fat Infusion on FIAT.- Interrelationship of Plasma Free Fatty Acids and Blood Beta-Hydroxybutyrate Concentration in Coronary Artery Disease.- Bile Acids.- Elimination of Cholesterol as Bile Acids in Hyperlipoproteinemias Type II and IV.- Bile Acid Kinetics in Hyperlipoproteinemia.- Miscellaneous.- Influence of Dietary Cholesterol on Skin Lipid Synthesis in Man. Evidence for a Positive Feedback Mechanism.- XII. Lipolytic Enzymes.- Workshop: Lipolytic Enzymes.- Observation Implicating that Familial Type I Hyperlipoproteinemia Is Not a Post-Heparin-Lipase Deficient Condition.- Separation and Characterization of Two Triglyceride Lipase Activities from Human Post-Heparin Plasma.- Selective Measurement of Lipoprotein Lipase and Hepatic Lipase in Post-Heparin Plasma.- Effect of Unsaturated Phosphatidylcholine on the Lipoprotein Lipase Activity In Vitro.- Lipolytic Activities of Hepatic Plasma Membrane Origin in Post-Heparin Plasma.- Assay of Activators for Serum Lipoprotein Lipase.- XIII. Factors Contributing to Genesis of Hyperlipoproteinemia and/or Atherosclerosis.- Immunological Factors.- Immunological Factors of Atherosclerosis.- Antibodies Against Vascular Antigens.- Hyperimmuno-Globulinemia-Lipoproteinemia and Atherogenesis.- Hypertension.- Workshop: Atherosclerosis-Hypertension Interrelationships.- Hormones.- Workshop: Hormones and Atherosclerosis.- Influence of Lipids on the Progesterone-Binding Affinity of Serum Albumin and ?1-Acid Glycoprotein.- The Influence of Exercise on Growth Hormone (STH)-Secretion in Males with Atherosclerotic Lesions.- Type III Hyperlipoproteinemia Secondary to Hypothyroidism.- XIV. Plasma Lipoproteins.- Workshop: Plasma Lipoproteins.- Function and Structure of Plasma Lipoproteins.- Lipoprotein Synthesis, Intracellular Transport and Secretion in Liver.- Lipoprotein Catabolism.- Comparative Electrophoretic Profiles of Serum Lipoproteins.- Studies on Apoliprotein D. A New Protein Moiety of the Human Plasma Lipoprotein System.- Characterization of Low Density Lipoproteins from Patients Homozygous for Familial Hyperbetalipoproteinaemia.- Lipoprotein Abnormalities Associated with Type III Hyperlipoproteinaemia.- Flotation Characteristics of the Lipoprotein Accumulated in the Plasma of Type III Patients.- Lipoprotein Pattern in Type III and Type IV Patients During Prolonged Fasting.- XV. Risk Factors.- Panel Discussion: Atherosclerosis: Risk Factor Screening and Early Diagnosis.- XVI. Prevention.- Panel Discussion: Prevention of Vascular Disease and its Consequence in Man.- Long-Term Hypolipidemic Treatment in the Prevention of Recurrent Coronary Heart Disease.- XVII. Dietary Management of Hyperlipoproteinemias.- Workshop: Dietary Management of Hyperlipoproteinemias.- Effects of Hypolipidemic Regimes on Serum Lipoproteins.- Influence of Various Diets on Diurnal Levels of Plasma Glucose, Insulin, and Lipids in Obesity and Insulin-Independent Diabetics.- Polyunsaturated Ruminant Fats and Cholesterol Metabolism in Man.- XVIII. Drug Therapy of Hyperlipoproteinemia.- Experience with Absorbable Drugs.- Workshop: Absorbable Drugs.- Effect of a New Hypolipidemic, Hypouricemic Agent (Halofenate) in Hyperlipoproteinemic Subjects.- A New Antiatherosclerotic Agent, EG467. Preliminary Report on its Experimental and Clinical Trial.- Long-Term Clofibrate Treatment in Familial Hyperlipoproteinemias.- Experience with Non-Absorbable Drugs.- Workshop: Management of Hyperlipoproteinemias with Non-Absorbable Drugs.- Enhancement of Cholesterol Metabolism by Colestipol Hydrochloride in Experimental Animals.- XIX. Surgical Treatment of Arteriosclerosis.- Workshop: Surgical Treatment of Arteriosclerosis.- Abstracts.- 1. Epidemiology.- 2. General Abstracts.- References.