This book showcases the results of the Euromech Colloquium 650, which aimed at fostering a deeper understanding of how artificial intelligence enhances applied mechanics. The selected papers highlight novel methodologies, innovative applications, and interdisciplinary approaches that address current challenges in mechanical system optimization, energy harvesting, material characterization, structural health monitoring, and vibration analysis. By bridging AI techniques with traditional mechanical engineering, this book offers valuable insights for researchers, industry professionals, and academic scholars working in applied mechanics, computational modelling, and intelligent system design.