Apolipoproteins: Evolution, Function, and Biomedical Significance is a comprehensive and up-to-date volume dedicated to exploring the molecular complexity and clinical relevance of apolipoproteins. Designed for researchers, clinicians, and graduate students in biomedical sciences, this book provides an integrated overview of the evolutionary origins, structural diversity, and physiological roles of apolipoproteins in lipid transport and metabolic regulation. The book examines the genetic and evolutionary pathways that shaped the apolipoprotein family. Detailed chapters address the molecular architecture of major apolipoproteins, their interactions with lipids and receptors, and their regulatory roles in lipoprotein metabolism. Particular emphasis is placed on mechanistic insights derived from molecular biology, structural biochemistry, and translational research. Beyond fundamental biology, this volume underscores the biomedical significance of apolipoproteins in health and disease. It discusses their involvement in cardiovascular disorders, metabolic syndrome, neurodegenerative diseases, tissue-specific diseases, câncer, infections, and other inflammatory conditions. The diagnostic value of apolipoproteins as biomarkers and their emerging role as therapeutic targets are critically evaluated, including advances in precision medicine and novel pharmacological strategies. By bridging evolutionary biology, structural science, and clinical application, Apolipoproteins: Evolution, Function, and Biomedical Significance offers a multidisciplinary perspective that supports both academic inquiry and clinical innovation.