Apc Proteins

APC and ?-Catenin Degradation.- Nuclear APC.- APC in Cell Migration.- The APC-EB1 Interaction.- The Role of APC in Mitosis and in Chromosome Instability.- Role of APC and Its Binding Partners in Regulating Microtubules in Mitosis.- The Adenomatous Polyposis Coli Tumor Suppressor and Wnt Signaling in the Regulation of Apoptosis.- APC and Its Modifiers in Colon Cancer.- Tissue-Specific Tumour Suppression byAPC.- Extra-Colonic Manifestations of Familial Adenomatous Polyposis Coli.

Inke Näthke is the professor of Epithelial Biology at the University of Dundee. Her research interest is to determine how specific molecular changes produce changes in cells and ultimately in whole tissues during early stages of tumourigenesis. Her focus is on colorectal cancers but the common epithelial origin of most tumours makes this work relevant to many other organs. Her work has led her to examine not only how cells move and divide but also how they know where they are, and how they work together to build a functional tissue. Professor Näthke received her training at San Jose State University, the University of California San Francisco, Stanford and Harvard Medical Schools.
Brooke McCartney is an Assistant Professor of Biological Sciences at Carnegie Mellon University. She is interested in how signaling pathways regulate the cytoskeleton and how this leads to changes in cytoskeletal and tissue architecture. The focus of her lab is therole of APC proteins and Wnt signaling in morphogenesis, both at the level of the cytoskeleton and at the level of tissues, using Drosophila melanogaster as a model system. Dr. McCartney received her training at Mount Holyoke College, Duke University, and the University of North Carolina at Chapel Hill.