Ankylosing Spondylitis is an insidious disease that is often difficult to diagnose in the early stages but which can cause progressive and sometimes severe disability. This handbook, written by international experts, clearly describes the features of ankylosing spondylitis and emphasizes the importance of accurate assessment . It then discusses the evidence regarding the evidence regarding the efficacy of established therapeutic options, and the more recently developed disease modifying and disease controlling anti rheumatic agents.