The first time Jamie meets Jim, she is a graduate student, and he is a dashing young man embarking on a successful career in pharmaceutical research. They cultivate a mutual affection for each other while pursuing different goals in life. When Jamie meets Jim again years later, she has broken up with her long-time boyfriend, and he is having marital problems. A one-night stand in a remote hotel turns their friendship into a two-decade long love affair. When their liaison becomes too difficult to sustain, it brings a crisis to its head. The accidental death of Jim's wife clears the way for the lovers, but instead of uniting with Jamie, Jim commits suicide. Suspenseful and gripping, An Intangible Affair is a tale of passion and deception, friendship and love.