Though ample amount of research; both pre-clinical and clinical, has been conducted during the past few years, Amyotrophic Lateral Sclerosis (ALS) continues to be one of the mysterious diseases of 21st century. Significant attempts have been made for the progress of pathophysiological models and understanding the underlying pathology, and with new instruments in genetics and transgenic techniques, the goal of finding a durable cure has come into scope. On the contrary, most pharmacological trials have remained unsuccessful in depicting an advantage for ALS patients. In this book, readers will find a compilation of state-of-the-art examination of etiology, epidemiology, and pathophysiology of ALS, including the advantages and pitfalls in experimental models of Amyotrophic Lateral Sclerosis.