St. Kleio Academy is a very exclusive school: all of the students are clones of famous historical figures such as Beethoven, Queen Elizabeth I, Napoleon, Mozart, and Freud. All of them, that is, except for Shiro Kamiya. As Shiro struggles to adapt to this unusual campus, St. Kleio's first graduate, the clone of John F. Kennedy, is killed. Are the clones doomed to repeat the fate of their genetic progenitors, or can they create their own destinies? And how does a normal boy like Shiro fit in?