Addressing Systems Safety Challenges contains papers presented at the twenty-second annual Safety-critical Systems Symposium, held in Brighton, UK, in February 2014. The Symposium is for engineers, managers and academics in the field of system safety, across all industry sectors, so the papers making up this volume offer a wide-ranging coverage of current safety topics, and a blend of academic research and industrial experience. They include both recent developments in the field and discussion of open issues and questions that will shape future progress. The topics covered by the papers in this volume include safety standards; safety of data-centric systems; safety cases in an explosives environment; railway safety; safety and security in healthcare; human factors; safety maturity modelling; aircraft system safety assessment; safety certification; safety-critical avionics displays; safety of software-based nuclear systems; common cause failures; safety acceptance decision processes; and compilation validation. This book will be of interest to practitioners, managers and academics working in the safety-critical systems arena.