A Tangled Web examines the depths of loyalty and deceit as seen through the lives of two best friends and their enemy. Nate Randall and Ben Stevens, two assistant prosecutors in Cleveland, Ohio, seek to bring down Josh Morgan, a street thug who has somehow built a multimillion dollar criminal organization. Nate must stay alive as Josh wages a campaign to terrorize him, and destroy his reputation. Ben is driven to utter frustration as his drive for justice alienates him from his colleagues and his family. His life is changed forever when his daughter is brutally murdered. He leaves the prosecutor's office and inexplicably agrees to defend Josh in a murder case. Nate must navigate a maze of contradictions as he seeks to battle his enemy, decipher his friend's actions and protect his family, only to ultimately discover an unimaginable truth.