About the Editors Timothy C. Wang, MD, Chief, Division of Digestive and Liver Diseases; Silberberg Professor of Medicine, Department of Medicine and Irving Cancer Research Center, Columbia University Medical Center, New York, NY, USA. Michael Camilleri, MD, Atherton and Winifred W. Bean Professor of Medicine, Pharmacology and Physiology, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA. Associate Editors Benjamin Lebwohl, MD, Associate Professor of Medicine and Epidemiology, Columbia University Medical Center, New York, NY, USA. Anna Lok, MD, Alice Lohrman Andrews Research Professor of Hepatology, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, USA. William J. Sandborn, MD, Professor of Medicine, University of California San Diego, CA, USA. Kenneth K. Wang, MD, Russell G. and Kathleen M. Van Cleve Professor of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA. Gary D. Wu, MD, Ferdinand G. Weisbrod Professor of Medicine, Division of Gastroenterology and Hepatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Contributors, ix Preface, xvii About the companion website, xviii PART 1 Anatomy and development 1 Esophagus: anatomy and structural anomalies, 3 Ikuo Hirano 2 Stomach and duodenum: anatomy and structural anomalies, 15 Erik C. von Rosenvinge and Jean-Pierre Raufman 3 Small intestine: anatomy and structural anomalies, 22 Deborah C. Rubin and Jacob C. Langer 4 Colon: anatomy and structural anomalies, 27 Bo Shen 5 Pancreas: anatomy and structural anomalies, 34 Kazuki N. Sugahara and John A. Chabot 6 Abdominal cavity: anatomy, structural anomalies, and hernias, 40 Stella Joyce, Kevin P. Murphy, Michael M. Maher, and Owen J. O'Connor 7 Gallbladder and biliary tract: anatomy and structural anomalies, 50 Theodore H. Welling 8 Liver: anatomy, microscopic structure, and cell types, 59 Maria Westerhoff and Laura Lamps PART 2 Gastrointestinal diseases A Esophagus 9 Motility disorders of the esophagus, 71 Joan W. Chen, John E. Pandolfino, and Peter J. Kahrilas 10 Gastroesophageal reflux disease, 83 Dustin A. Carlson, John E. Pandolfino, and Peter J. Kahrilas 11 Eosinophilic esophagitis, 97 Yael Haberman Ziv, Margaret H. Collins, Nirmala Gonsalves, David A. Katzka, and Marc E. Rothenberg 12 Esophageal infections and disorders associated with acquired immunodeficiency syndrome, 100 C. Mel Wilcox 13 Esophageal neoplasms, 108 Adam J. Bass and Anil K. Rustgi 14 Miscellaneous diseases of the esophagus, 118 Craig C. Reed, Evan S. Dellon, and Nicholas J. Shaheen B Stomach 15 Disorders of gastric emptying, 131 Henry P. Parkman MD 16 Peptic ulcer disease, 141 Jonathan R. White, Krish Ragunath, and John C. Atherton 17 Zollinger-Ellison syndrome, 153 Robert T. Jensen and David C. Metz 18 Gastritis and gastropathy, 159 M. Blanca Piazuelo, Richard M. Peek, Jr, and M. Kay Washington 19 Tumors of the stomach, 170 Philip I. Craig and Emad M. El-Omar 20 Miscellaneous diseases of the stomach, 177 Tamas A. Gonda and Abraham Krikhely C Small intestine 21 Dysmotility of the small intestine and colon, 182 David O. Prichard and Lawrence Szarka 22 Disorders of epithelial transport, metabolism, and digestion in the small intestine, 190 Richard J. Grand 23 Celiac disease, 196 Daniel A. Leffler and Benjamin Lebwohl 24 Short bowel syndrome and small bowel transplantation, 204 John K. DiBaise, Samuel Kesseli, and Debra Sudan 25 Bacterial, viral, and toxic causes of diarrhea, gastroenteritis, and anorectal infections, 209 Gail A. Hecht, Jerrold R. Turner, Phillip I. Tarr, and Mitchell B. Cohen 26 Chronic infections of the small intestine, 216 Beth Gordon, Mary Flanagan, and Séamus Hussey 27 Tumors of the small intestine, 225 Barbara H. Jung and Maria Rosario Ferreira 28 Miscellaneous diseases of the small intestine, 231 Marc S. Levin D Inflammatory bowel disease 29 Ulcerative colitis: clinical manifestations and management, 239 Siddharth Singh 30 Crohn's disease: clinical manifestations and management, 255 Gil Y. Melmed, Christina Ha, and Dermot P.B. McGovern E Colon 31 Irritable bowel syndrome, 264 Elizabeth J. Videlock and Lin Chang 32 Diverticular disease of the colon, 280 Mona Rezapour and Neil Stollman 33 Anorectal diseases, 287 Adil E. Bharucha and Arnold Wald 34 Polyps of the colon and rectum, 304 Daniel C. Chung and John J. Garber 35 Malignant tumors of the colon, 309 Amin K. Soltani, Jay Luther, and Andrew T. Chan 36 Polyposis syndromes, 317 Marcia Cruz-Correa and Gabriella Torres 37 Colorectal cancer screening, 336 Uri Ladabaum F Pancreas 38 Acute pancreatitis, 341 Timothy B. Gardner 39 Chronic pancreatitis, 358 Mitchell L. Ramsey, Zarine K. Shah, Darwin L. Conwell, and Phil A. Hart 40 Pancreatitis of genetic and complex etiologies, 365 David C. Whitcomb 41 Cystic lesions of the pancreas, 375 James J. Farrell 42 Neuroendocrine tumors of the pancreas, 383 Yasmin G. Hernandez-Barco and Daniel C. Chung G Gallbladder and biliary tract 43 Gallstones, 389 Piero Portincasa and David Q.-H. Wang 44 Primary sclerosing cholangitis, 408 Ahmad Hassan Ali and Konstantinos N. Lazaridis 45 Cystic diseases of the liver and biliary tract, 416 James L. Buxbaum and Shelly C. Lu 46 Tumors of the biliary tract, 423 Tushar Patel and Victoria Gomez H Liver 47 Acute viral hepatitis, 431 Marc G. Ghany and T. Jake Liang 48 Chronic hepatitis B and D, 447 Grace L.H. Wong and Anna S. Lok 49 Chronic hepatitis C, 456 Hugo E. Vargas and Andrew W. Tai 50 Drug-induced liver injury, 462 Robert J. Fontana 51 Autoimmune hepatitis, 471 Richard Taubert and Michael P. Manns 52 Primary biliary cholangitis, 476 Marlyn J. Mayo 53 Acute cholangitis and liver abscess, 483 Roman E. Perri and David S. Raiford 54 Hemochromatosis, 486 Paul C. Adams 55 Metabolic diseases of the liver, 490 Jacob Bilhartz and Frederick K. Askari 56 Alcohol-related liver disease, 496 Juan Pablo Arab, Stephen R. Atkinson, and Ramon Bataller 57 Nonalcoholic fatty liver disease, 499 Mohammad S. Siddiqui and Arun J. Sanyal 58 Hepatic fibrosis and cirrhosis, 506 Don C. Rockey 59 Ascites and its complications, 522 Guadalupe Garcia-Tsao 60 Vascular diseases of the liver, 532 José Ferrusquía-Acosta and Laurie D. DeLeve 61 Liver transplantation, 538 Alyson J. Kaplan, Nicole T. Shen, Alyson N. Fox, and Robert S. Brown, Jr 62 Hepatocellular carcinoma, 544 Jorge A. Marrero and Nicole E. Rich I Miscellaneous 63 Intraabdominal abscesses and fistulas, 549 Ravi Pokala Kiran 64 Diseases of the peritoneum, retroperitoneum, mesentery, and omentum, 556 Jennifer M. Whittington, Scott D. Stevens, and B. Mark Evers 65 Obesity: treatment and complications, 564 Harmeet Malhi and Andres Acosta 66 Surgical complications of metabolic surgery, 575 Todd A. Kellogg, Joseph N. Badaoui, and Omar M. Ghanem 67 Complications of HIV/AIDS and other secondary immunodeficiency states, 588 Phillip D. Smith, C. Mel Wilcox, and Edward N. Janoff 68 Gastrointestinal manifestations of immunological disorders, 596 Paula O'Leary and Fergus Shanahan 69 Parasitic diseases: protozoa, 602 Daniel P. Beiting and Audrey R. Odom John 70 Parasitic diseases: helminths, 611 Joel V. Weinstock 71 Gastrointestinal manifestations of systemic diseases, 629 Seth Sweetser 72 Skin lesions associated with gastrointestinal and liver diseases and oral manifestations of gastrointestinal diseases, 641 Travis W. Vandergriff 73 Intestinal ischemia and vasculitides, 662 Juan-Ramón Malagelada and Carolina Malagelada 74 Radiation injury in the gastrointestinal tract, 677 Lalitha S. Y. Nanduri, Nicole C. Panarelli, and Chandan Guha PART 3 Diagnostic and therapeutic modalities in gastroenterology A Endoscopic 75 Upper gastrointestinal endoscopy, 687 Emmanuel Coronel and Irving Waxman 76 Capsule and small bowel endoscopy, 713 Jonathan A. Leighton and Shabana F. Pasha 77 Colonoscopy and sigmoidoscopy, 718 Douglas K. Rex 78 Endoscopic retrograde cholangiopancreatography, 724 Todd H. Baron and Ryan J. Law 79 Gastrointestinal dilation and stent placement, 728 Shayan Irani and Richard A. Kozarek 80 Management of upper gastrointestinal hemorrhage related to portal hypertension, 750 Patrick S. Kamath and Louis-Michel Wong Kee Song 81 Endoscopic diagnosis and treatment of nonvariceal upper gastrointestinal hemorrhage, 769 Andrew W. Yen and Joseph W. Leung 82 Endoscopic management of esophageal, gastric, and duodenal lesions, 775 Neal Shahidi, Sunil Gupta, and Michael J. Bourke 83 Endoscopic management of colorectal lesions, 782 Neal Shahidi, Sunil Gupta, and Michael J. Bourke 84 Minimally invasive surgery: laparotomy, laparoscopy, and robotic surgery, 788 Aashish Rajesh, Nizamuddin Shaikh, and David R. Farley B Imaging 85 POEM and G-POEM, 796 Mary Raina Angeli Fujiyoshi, Haruhiro Inoue, Yusuke Fujiyoshi, Yuto Shimamura, Haruo Ikeda, and Manabu Onimaru 86 Plain and contrast radiology, 801 Stephen E. Rubesin and Marc S. Levine 87 Abdominal sonography, 813 Stuart Bentley-Hibbert and Dwight Aberle 88 Endoscopic ultrasonography, 822 Margaret G. Keane, Anne Marie Lennon, and Mouen A. Khashab 89 Computed tomography of the gastrointestinal tract, 835 Eric C. Ehman, Siva P. Raman, Karen M. Horton, Pamela T. Johnson, and Elliot K. Fishman 90 Magnetic resonance imaging, 847 Haresh Naringrekar 91 Positron emission tomography, 870 Garima Suman and Val J. Lowe 92 Nuclear medicine imaging, 893 Mathurika Jeyasingam and Harvey A. Ziessman 93 Abdominal angiography, 910 Kyung Jae Cho C Pathology 94 Interventional radiology, 932 Sidney Z. Brejt and Sergei A. Sobolevsky 95 Liver biopsy and histopathological diagnosis, 953 Sugantha Govindarajan 96 Endoscopic mucosal biopsy: histopathological interpretation, 971 Antonia R. Sepulveda and Sun A. Kim Index, 995