Transporters as Drug Targets (Methods and Principles in Medicinal Chemistry)

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Notă GoodReads:
en Limba Engleză Carte Hardback – 08 Feb 2017
As opposed to other books on the topic, this volume is unique in also covering emerging transporter targets.
Following a general introduction to the importance of targeting transporter proteins with drugs, the book systematically presents individual transporter classes and explains their pharmacology and physiology. The text covers all transporter families with known or suspected importance as drug targets, including neurotransmitter transporters, ABC transporters, glucose transporters and organic ion transporters. The final part discusses recent advances in structural studies of transport proteins, assay methods for transport activity, and the systems biology of transporters and their regulation.
With its focus on drug development issues, this authoritative overview is required reading for researchers in industry and academia targeting transport proteins for the treatment of disease.
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ISBN-13: 9783527333844
ISBN-10: 3527333843
Pagini: 334
Dimensiuni: 170 x 244 x 170 mm
Greutate: 0.91 kg
Editura: Wiley Vch
Seria Methods and Principles in Medicinal Chemistry

Locul publicării: Weinheim, Germany

Public țintă

Medicinal Chemists, Biochemists, Biophysicists, Pharmaceutical Chemists, Pharmaceutical Industry


Targeting the Transportome

Biogenic Amine Transporters: New Trends in Alzheimer′s Disease Research
Biogenic Amine Transporters: Molecular Basis of Drug–Transporter Interaction
Excitatory Amino Acid Transporters
Inhibitory Amino Acid Transporters
Glucose Transporter: GLUT/SGLT as Target
Transporters Related to Drug Resistance
Transporters Involved in Cholestasis
TAP1/TAP2 as Drug Targets
Emerging Targets: Organic Cation Transporters (OCT1, OCT3)
Emerging Targets: Organic Anion Transporter (OAT1)

Structural Approaches: ABC Transporter
Structural Approaches: LeuT as Template for NSS
Structural Approaches: NaC–coupled Glutamate Transporter Homolog
ABCB1/ABCG2 PET Ligands for Imaging the Blood–Brain Barrier
FRET/LRET Approaches for Probing NSS Transporter
The Systems Biology of Transporters

Notă biografică

Gerhard Ecker is Full Professor for Pharmacoinformatics at the Department of Medicinal Chemistry, University of Vienna (Austria). He is also President of the European Federation for Medicinal Chemistry (EFMC). His main scientific interests are pharmacoinformatic approaches to target drug transporters, in silico screening methods for promiscuous targets and antitargets, and non-linear methods in drug design. Rasmus Prætorius Clausen is Associate Professor at Dept. Drug Design and Pharmacology, University of Copenhagen (former Royal School of Pharmacy) where he also did post-doctoral studies with P. Krogsgaard-Larsen. His main research topics are neuromedicinal chemistry with focus on glutamate, GABA and GHB, and epigenetic medicinal chemistry. He has a M.Sc. degree from University of Southern Denmark (Chemistry/Cell Biology) and a PhD degree from the University of Aarhus (Denmark). Harald Sitte studied Medicine at the Universities of Innsbruck and Vienna (Austria). He was appointed Professor for Psychopharmacology at Vienna Medical University in 2010. His main scientific research interests are the structure-function relationships in neurotransmitter transporters and the pharmacological activity of psychopharmacological medicines and drugs of abuse.