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Smith and Williams' Introduction to the Principles of Drug Design and Action

Autor H. John Smith, Hywel Williams
en Limba Engleză Hardback – 10 oct 2005
Advances in knowledge and technology have revolutionized the process of drug development, making it possible to design drugs for a given target or disease. Building on the foundation laid by the previous three editions, Smith and Williams’ Introduction to the Principles of Drug Design and Action, Fourth Edition includes the latest information on topics such as gene therapy, computer-aided design, and molecular techniques including proteomics. Using real-world examples that illustrate the principles of drug design, the author explores the discovery of lead compounds and their manipulation in the production of non-toxic, metabolically stable drug candidates that will interact with target receptors in a predicted fashion. See what’s new in the Fourth Edition:
Fully updates and expands the contents
Coverage of agonists and antagonists of neuro-transmitters
Information on the design of stable peptide-like drugs
The human genome and its impact on drug discovery and development
Advances in therapy and pharmacokinetics
Adopting a from-the-bench-to-the-marketplace approach, the book provides a thorough grounding in rational drug design. It emphasizes principles and elucidates a framework for basic drug design into which current and, more importantly, future drugs will fit.
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Specificații

ISBN-13: 9780415288774
ISBN-10: 0415288770
Pagini: 682
Dimensiuni: 181 x 261 x 43 mm
Greutate: 1.6 kg
Ediția:4Revizuită
Editura: Taylor & Francis Ltd.

Public țintă

Pharmacists and medicinal chemists

Cuprins

Contents
Processes of Drug Handling by the Body, M. Gumbleton
The Design of Drug Delivery Systems, I.W. Kellaway
Fundamental Pharmacokinetics, G. Taylor
Intermolecular Forces and Molecular Modeling, R.H. Davies
Drug Chirality and its Pharmacological Consequences, A.J. Hutt
Quantitative StructureߝActivity Relationships (QSAR) in Drug Design, J.C. Dearden and M.T.D. Cronin
Prodrugs, A.W. Lloyd
From Program Sanction to Clinical Trials: A Partial View of the Quest for Arimidex, A Potent, Selective Inhibitor of Aromatase, P.N. Edwards
Design of Enzyme Inhibitors as Drugs, A. Patel, H.J. Smith, and T. Steinmetzer
Peptide Drug Design, D.J. Barlow
Combinatorial Chemistry: A Tool for Drug Discovery, B. Kellam
Recombinant DNA Technology: Monoclonal Antibodies, F.J. Rowell
The Human Genome and its Impact on Drug Discovery and Therapy, F.J. Rowell
The Chemotherapy of Cancer, D.E. Thurston
Neurotransmitters, Agonists, and Antagonists, R.D.E. Sewell, H.J. Smith, H. Stark, W. Schunack, and P.G. Strange
Design of Antibacterial, Antifungal, and Antiviral Agents, C. Simons and A.D. Russell
Pharmaceutical Applications of Bioinorganic Chemistry, D.M. Taylor and D.R. Williams Index