Preclinical Drug Development: Drugs and the Pharmaceutical Sciences, cartea 187
Editat de Mark C. Rogge, David R. Taften Limba Engleză Hardback – sep 2009
Highlights of the Second Edition include:
- Pharmacokinetics
- Modeling and simulation
- Formulation and routes of administration
- Toxicity evaluations
- The assessment of drug absorption and metabolism
- Interspecies scaling
- Lead molecule selection and optimization via profiling
- Screening using in silico and in vitro toxicity evaluations
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Specificații
ISBN-13: 9781420084726
ISBN-10: 1420084720
Pagini: 359
Ilustrații: 58 b/w images and 16 color images
Dimensiuni: 180 x 254 x 25 mm
Greutate: 0.82 kg
Ediția:Revizuită
Editura: Informa Medical
Seria Drugs and the Pharmaceutical Sciences
ISBN-10: 1420084720
Pagini: 359
Ilustrații: 58 b/w images and 16 color images
Dimensiuni: 180 x 254 x 25 mm
Greutate: 0.82 kg
Ediția:Revizuită
Editura: Informa Medical
Seria Drugs and the Pharmaceutical Sciences
Public țintă
Medicinal chemists, biologists, pharmacologists, and toxicologists in drug development; and academic faculty and studentsCuprins
The Scope of Preclinical Drug Development: An Introduction and Framework; Mark C. Rogge
Lead Molecule Selection: Pharmaceutical Profiling and Toxicity Assessments; P. L. Bullock
Interspecies Differences in Physiology and Pharmacology: Extrapolating Preclinical
Data to Human Populations; M. N. Martinez
Pharmacokinetics/ADME of Small Molecules; A. D. Ajavon and David R. Taft
Pharmacokinetics/ADME of Large Molecules; R. Braeckman
Preclinical PharmacokineticߝPharmacodynamic Modeling and Simulation in Drug Development; P. L. Bonate and P. Vicini
Formulation and Production Strategies for Enhancing Bioavailability of Poorly Absorbed Drugs; A. B. Watts and R. O. Williams III
Transporters Involved in Drug Disposition, Toxicity, and Efficacy; C. Q. Xia and G. T. Miwa
Toxicity Evaluations, ICH Guidelines, and Current Practice; J. L. Larson
Application of Pathology in Safety Assessment; Robert A. Ettlin and David E. Prentice
Utilizing the Preclinical Database to Support Clinical Drug Development; H. Lee
Index
Lead Molecule Selection: Pharmaceutical Profiling and Toxicity Assessments; P. L. Bullock
Interspecies Differences in Physiology and Pharmacology: Extrapolating Preclinical
Data to Human Populations; M. N. Martinez
Pharmacokinetics/ADME of Small Molecules; A. D. Ajavon and David R. Taft
Pharmacokinetics/ADME of Large Molecules; R. Braeckman
Preclinical PharmacokineticߝPharmacodynamic Modeling and Simulation in Drug Development; P. L. Bonate and P. Vicini
Formulation and Production Strategies for Enhancing Bioavailability of Poorly Absorbed Drugs; A. B. Watts and R. O. Williams III
Transporters Involved in Drug Disposition, Toxicity, and Efficacy; C. Q. Xia and G. T. Miwa
Toxicity Evaluations, ICH Guidelines, and Current Practice; J. L. Larson
Application of Pathology in Safety Assessment; Robert A. Ettlin and David E. Prentice
Utilizing the Preclinical Database to Support Clinical Drug Development; H. Lee
Index