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Polycystic Kidney Disease: Translating Mechanisms into Therapy

Editat de Benjamin D. Cowley, Jr., John J. Bissler
en Limba Engleză Paperback – 25 iul 2019
This comprehensive guide to polycystic kidney disease captures the growing knowledge of this common, potentially-fatal and hereditary disease.  The first two sections of the book provide an overview of PKD gene structures, mutations and pathophysiologic mechanisms.  This is followed by chapters focused on PKD’s clinical features, including renal and extrarenal manifestations, and appropriate management of patients.  The final section covers current clinical trials and emerging therapies in PKD.  Authored by experts in the field, this book provides the clinician and researcher with critical information on basic and translational science and clinical approaches in one concise resource.
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Specificații

ISBN-13: 9781493992843
ISBN-10: 1493992848
Pagini: 273
Ilustrații: XIII, 273 p. 62 illus., 42 illus. in color.
Dimensiuni: 178 x 254 mm
Greutate: 0.55 kg
Ediția:Softcover reprint of the original 1st ed. 2018
Editura: Springer
Colecția Springer
Locul publicării:New York, NY, United States

Cuprins

PART 1.  POLYCYSTIC KIDNEY DISEASE GENES & PROTEINS1. Classical Polycystic Kidney Disease (PKD): Gene Structures and Mutations and Protein Structures and Functions
2. Bardet-Biedl Syndrome
3. Cystic Kidney Diseases Associated with Increased Cancer Risk: Tuberous Sclerosis Complex, Von Hippel Lindau, and Birt Hogg DubéPART 2. POLYCYCSTIC KIDNEY DISEASE: MECHANISMS OF DISEASE
4. Aberrant Cellular Pathways in PKD
5. Cilia and Polycystic Kidney Disease6. The Role of Inflammation and Fibrosis in Cystic Kidney Disease
PART 3. CLINICAL FEATURES
7. Imaging-based Diagnosis of Autosomal Dominant Polycystic Kidney Disease
8. Renal Structural Involvement in Autosomal Dominant Polycystic Kidney Disease: Cyst Growth and Total Kidney Volume: Lessons from the Consortium for Radiologic Imaging of Polycystic Kidney Disease (CRISP)
9. Renal Complications: Pain, Infection and Nephrolithiasis 10. ADPKD Extrarenal Manifestations: Polycystic Liver Disease11. Extrarenal Manifestations of Autosomal Dominant Polycystic Kidney Disease
PART 4. CLINICAL TRIALS AND EMERGING THERAPIES
12.  Role of Renin- Angiotensin- Aldosterone System Inhibition in Autosomal Dominant Polycystic Kidney Disease
13. Vasopressin Receptor Antagonism
14. End-stage Renal Disease in Patients with Autosomal Dominant Polycystic Kidney Disease
15. Polycystic Kidney Disease: Translating Mechanisms into Therapy Management of ADPKD Today

Notă biografică

John J. Bissler, MD
Federal Express Chair of Excellence, Professor and Chief, Division of Nephrology, Department of Pediatrics, Director of the Tuberous Sclerosis Center of Excellence at Le Bonheur Children’s Hospital, Medical Director of Nephrology, St. Jude Children's Research Hospital, University of Tennessee Health Science Center
University of Tennessee Health Science Center
Children’s Foundation Research Center
Memphis, TN 


Benjamin D. Cowley, Jr., M.D., F.A.C.P., F.A.S.N.
Professor of Medicine
Chief, Nephrology & Hypertension
John Gammill Professor in Polycystic Kidney Disease
University of Oklahoma Health Sciences Center
Oklahoma City, OK



Textul de pe ultima copertă

This comprehensive guide to polycystic kidney disease captures the growing knowledge of this common, potentially-fatal and hereditary disease.  The first two sections of the book provide an overview of PKD gene structures, mutations and pathophysiologic mechanisms.  This is followed by chapters focused on PKD’s clinical features, including renal and extrarenal manifestations, and appropriate management of patients.  The final section covers current clinical trials and emerging therapies in PKD.  Authored by experts in the field, this book provides the clinician and researcher with critical information on basic and translational science and clinical approaches in one concise resource.

Caracteristici

Provides a comprehensive review of PKD mutations, pathophysiologic mechanisms of PKD, renal and extrarenal manifestations of PKD, clinical trials and emerging therapies in PKD, and appropriate management of patients with PKD
Written by top professionals in the field
Well-illustrated resource serves both clinician and researcher