In this issue of Nursing Clinics of North America, guest editors Connie Braybrook and Pamela Wall bring their considerable expertise to the topic of Policy, Innovation, and Diversity: A Blueprint for Mental Health Transformation. Transforming mental health care is a top global priority, with the primary care nurse at its core. This special issue in mental health represents a vision of the future of mental health nursing with the main aim of optimizing health outcomes and reducing the disease burden.