Pancreatic Cancer

Editat de John P. Neoptolemos, Raul A. Urrutia, James Abbruzzese, Markus W. Büchler
en Limba Engleză Electronic book text – 04 Dec 2009
This handbook details advances in pancreatic cancer research that have a profound and lasting impact on the field. It features the work of authors who are the very best in their respective fields and will have widespread appeal among clinicians, pathologists and basic scientists who are now struggling to understand this complex and rapidly expanding field.
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ISBN-13: 9780387774985
ISBN-10: 038777498X
Dimensiuni: 155 x 235 mm
Ediția: 2010
Editura: Springer
Colecția Springer
Locul publicării: New York, NY, United States

Public țintă



Section One: The Nature of Pancreatic Cancer
  1. Epidemiology: world overview, risk factors, prospects for prevention
  2. Development and structure of pancreas
  3. Pathologic classification and biological behaviour of pancreatic neoplasia
  4. Developmental molecular biology of the pancreas
  5. Molecular pathology of precursor lesions of pancreatic cancer, pancreatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasm (IPMN), and mucinous cystic neoplasm (MCN)
  6. Epigenetics: its fundamentals and applications to a revised comprehensive progression model for pancreatic cancer
  7. Molecular pathology of pancreatic neuroendocrine tumours MEN-1: gastrinomas, insulinoma, Non-Functioning Tumours, VIPoma, glucagonoma, Von Hippel-Lindau, Neurofibromatosis
  8. Sporadic neuroendocrine pancreatic tumours
  9. Molecular pathology of non-pancreatic cancer lesions: Ampullary cancer, intra-pancreatic bile duct cancer, and duodenal cancer
  10. Miscellaneous non-pancreatic non-endocrine tumours
  11. Novel molecular relationships between chronic pancreatitis and cancer
  12. Pancreatic cancer stem cells
  13. Cell cycle control: signalling pathways in pancreatic pathogenesis
  14. Apoptosis: signalling pathways in pancreatic pathogenesis
  15. EGFR: signalling pathways in pancreatic pathogenesis Pl3, Akt, lKK, Ras, Raf, MAPKK, ERK
  16. Hedgehog: signalling pathways in pancreatic pathogenesis
  17. Smad4/TGF-ß pathway: signalling pathways in pancreatic pathogenesis
  18. Notch signalling in pancreatic morphogenesis and pancreatic cancer
  19. Molecular characterization of pancreatic cell lines
  20. Mouse models of exocrine pancreatic cancer
  21. Principles and applications of microarray gene expression in pancreatic cancer
  22. Principles and applications of proteomics in pancreatic cancer
  23. Tumour-stromal interaction: invasion and metastases
  24. Genetic susceptibility, high risk groups, chronic and hereditary pancreatitis, familial pancreatic cancer syndromes
  25. Inherited endocrine pancreatic tumors associated with Multiple Endocrine Neoplasia Type 1 Von-Hippel-Lindau Syndrome, and Neurofibromatosis Type 1  
    Section Two: Clinical Management of Pancreatic Cancer
  26. Clinical decision making in pancreatic cancer
  27. Paraneoplastic syndromes
  28. Diagnostic and therapeutic response markers
  29. CT and fusion PET-CT Diagnosis, staging, and follow-up
  30. MRI and MRCP: diagnosis and staging of pancreatic cancer
  31. EUS Diagnosis and staging
  32. Laparoscopy and laparoscopic ultrasound: diagnosis and staging
  33. Overview of palliative management for pancreatic cancer
  34. Endoscopy.
  35. Interventional radiology
  36. Role of palliative surgery in advanced pancreatic cancer
  37. Chemotherapy for advanced pancreatic cancer
  38. Developments in chemoradiation in advanced pancreatic cancer
  39. Surgical resection for pancreatic cancer
  40. Role of venous resection in pancreatic cancer surgery
  41. Pathological reporting and staging following resection
  42. Japanese Pancreas Society staging for pancreatic cancer
  43. Adjuvant chemotherapy in pancreatic cancer
  44. Case for adjuvant chemoradiation therapy for pancreatic cancer
  45. Case for neoadjuvant treatment in pancreatic cancer
  46. Borderline resectable disease
  47. Management of cystic neoplasms serous cystic neoplasms mucinous, cystic neoplasms, intraductal paillary mucinous neoplasms
  48. Laparoscopic surgery for pancreatic neoplasm
  49. Modern Japanese approach to pancreas cancer  
    Section Three: New Directions
  50. Development of novel biomarkers
  51. Inherited genetics of pancreatic cancer and secondary screening
  52. Gene therapy for pancreatic cancer
  53. Vaccine therapy and immunotherapy
  54. Emerging targets in pancreatic cancer

Notă biografică

John Neoptolemos is Professor of Surgery and Head of the Division of Surgery and Oncology at the University of Liverpool and Honorary Consultant Surgeon at the Royal Liverpool University Hospital. As an undergraduate he studied Natural Sciences at Cambridge (BA 1973, MA 1976) before completing his clinical undergraduate training at Guys Hospital (Cambridge: MB, BChir 1976). He completed his academic and clinical training in Leicester under Prof. Sir Peter Bell, being awarded a Doctorate in Medicine in 1986.
Raul A. Urrutia, M.D., Mayo Clinic College of Medicine, Rochester, MN USA. Dr. Urrutia was awarded his M.D., Magna Cum Laude, by the University of Cordoba, Argentina.
Dr. James L. Abbruzzese is the Chairman of the Department of Gastrointestinal Medical Oncology at the University of Texas M. D. Anderson Cancer Center, Houston, Texas, where he holds the Annie Laurie Howard Research Distinguished Professorship. Author of over 150 original articles and book chapters, Dr. Abbruzzese has recently been appointed the Editor-in-Chief of the International Journal of Pancreatology. He serves on the editorial board of a number of prestigious journals, including the Journal of Clinical Oncology and Clinical Cancer Research, and also serves on the Scientific Advisory Board of the Lustgarten Foundation for Pancreatic Cancer Research.
Markus W. Büchler is Professor of Surgery at the University of Heidelberg, Germany. He studied medicine at the Universities of Heidelberg and Berlin and was trained in surgery at the Department of Surgery, University of Ulm, where he was appointed a Consultant Surgeon in 1987 and Vice Chairman in 1991. Professor Büchler is a specialist in hepato-pancreato-biliary surgery (HPB) and, in particular, pancreatic surgery. He has a substantial curriculum of scientific publications in the field of HPB diseases, especially in translational research of pancreatic cancer. He is Editor or Editorial Board member of many leading journals in general and gastrointestinal surgery, translational and molecular research in pancreatology and other gastrointestinal diseases, including Annals of Surgery, British Journal of Surgery. Digestive Surgery (Editor), Pancreas, Langenbeck's Archive of Surgery (Editor), HPB, and Surgery.


The only Major Reference Work devoted entirely to pancreatic cancer
The contributing authors to this book are the very best in their respective fields
Will have widespread appeal among clinicians, pathologists, and basic scientists who are now struggling to understand this complex and rapidly growing field