This volume constitutes the refereed proceedings of ten international workshops, OTM Academy, Industry Case Studies Program, EI2N, INBAST, Meta4eS, OnToContent, ORM, SeDeS, SINCOM and SOMOCO 2012, held as part of OTM 2012 in Rome, Italy, in September 2012. The 66 revised full papers presented were carefully reviewed and selected from a total of 127 submissions. The volume also includes 7 papers from the On the Move Academy (OTMA) 2012 as well as 4 CoopIS 2012 poster papers and 5 ODBASE 2012 poster papers. The paper cover various aspects of computer supported cooperative work (CSCW), middleware, Internet/Web data management, electronic commerce, enterprise modelling, workflow management, knowledge flow, agent technologies, information retrieval, software architectures, service-oriented computing, and cloud computing.