In this issue of Radiologic Clinics, guest editors Drs. Shannon P. Sheedy and Kevin J. Chang bring their considerable expertise to the topic of Imaging of the Small Bowel and Colon. Top experts focus mainly on MRI and CT modalities, with specific articles on small bowel tumors, Crohn’s disease, rectal MRI, anal MRI, CT colonography, traumatic injuries, iatrogenic injuries, and MR defecography, as well as artificial intelligence applications in the GI tract.