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Holland–Frei Cancer Medicine

Editat de Robert C. Bast, Jr. , Carlo M. Croce , William N. Hait , Waun Ki Hong , Donald W. Kufe , Martine Piccart–Gebhart , Raphael E. Pollock , Ralph R. Weichselbaum , Hongyang Wang , James F. Holland
en Limba Engleză Carte Hardback – 14 Mar 2017

Notă GoodReads:
The original reference resource for medical oncologists, radiation oncologists, internists, and allied specialties involved in the treatment of cancer patients, Holland–Frei Cancer Medicine covers the ever–expanding field of current cancer science and clinical oncology practice. In this new ninth edition an outstanding editorial team from world–renowned medical centers continue to hone the leading edge forged in previous editions, with timely information on biology, immunology, etiology, epidemiology, prevention, screening, pathology, imaging, and therapy.
Holland–Frei Cancer Medicine, Ninth Edition, brings scientific principles into clinical practice and is a testament to the ethos that innovative, comprehensive, multidisciplinary treatment of cancer patients must be grounded in a fundamental understanding of cancer biology.
This ninth edition features hundreds of full color illustrations, photographs, tables, graphs and algorithms that enhance understanding of complex topics and make this text an invaluable clinical tool. Over 15 brand new chapters covering the latest advances, including chapters Cancer Metabolism, Bioinformatics, Biomarker Based Clinical Trial Design, Health Services Research and Survivorship bring this comprehensive resource up–to–date. Each chapter contains overview boxes, select references and other pedagogic features, designed to make the content easy to access and absorb. The full list of references for each chapter are available on the free Wiley Companion Digital Edition.
Inside this completely updated Ninth Edition you ll find:
  • A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease
  • An emphasis on multidisciplinary, research–driven patient care to improve outcomes and optimal use of all appropriate therapies
  • Cutting–edge coverage of personalized cancer care, including molecular diagnostics and therapeutics
  • Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs
  • Free access to the Wiley Companion Digital Edition providing search across the book, full reference list with web links, downloadable illustrations and photographs, and post publication updates to key chapters  
Edited and authored by an international group of some of the best–known oncologists, cancer researchers, surgeons, pathologists, and other associated specialists in the world, and endorsed by the American Association of Cancer Research Holland–Frei Cancer Medicine offers a genuinely international view of cancer research and clinical oncology practice.
Endorsed by the American Association of Cancer Research
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Specificații

ISBN-13: 9781118934692
ISBN-10: 1118934695
Pagini: 2008
Dimensiuni: 227 x 285 x 69 mm
Greutate: 4.51 kg
Ediția: 9th Edition
Editura: Wiley
Locul publicării: Hoboken, United States

Public țintă

All clinical oncologists medical, radiation, and surgical oncologists and clinical oncology trainees, residents, fellows, house officers. All cancer researchers and cancer researchers in training.

Textul de pe ultima copertă

The original reference resource for medical oncologists, radiation oncologists, internists, and allied specialties involved in the treatment of cancer patients, Holland–Frei Cancer Medicine covers the ever–expanding field of current cancer science and clinical oncology practice. In this new ninth edition an outstanding editorial team from world–renowned medical centers continue to hone the leading edge forged in previous editions, with timely information on biology, immunology, etiology, epidemiology, prevention, screening, pathology, imaging, and therapy.
Holland–Frei Cancer Medicine, Ninth Edition, brings scientific principles into clinical practice and is a testament to the ethos that innovative, comprehensive, multidisciplinary treatment of cancer patients must be grounded in a fundamental understanding of cancer biology.
This ninth edition features hundreds of full color illustrations, photographs, tables, graphs and algorithms that enhance understanding of complex topics and make this text an invaluable clinical tool. Over 15 brand new chapters covering the latest advances, including chapters Cancer Metabolism, Bioinformatics, Biomarker Based Clinical Trial Design, Health Services Research and Survivorship bring this comprehensive resource up–to–date. Each chapter contains overview boxes, select references and other pedagogic features, designed to make the content easy to access and absorb. The full list of references for each chapter are available on the free Wiley Companion Digital Edition.
Inside this completely updated Ninth Edition you ll find:
  • A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease
  • An emphasis on multidisciplinary, research–driven patient care to improve outcomes and optimal use of all appropriate therapies
  • Cutting–edge coverage of personalized cancer care, including molecular diagnostics and therapeutics
  • Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs
  • Free access to the Wiley Companion Digital Edition providing search across the book, full reference list with web links, downloadable illustrations and photographs, and post publication updates to key chapters  
Edited and authored by an international group of some of the best–known oncologists, cancer researchers, surgeons, pathologists, and other associated specialists in the world, and endorsed by the American Association of Cancer Research Holland–Frei Cancer Medicine offers a genuinely international view of cancer research and clinical oncology practice.
Endorsed by the American Association of Cancer Research

Cuprins

Part 1: INTRODUCTION
1 Cardinal manifestations of cancer 00
James F. Holland, Waun K. Hong,DonaldW. Kufe, Robert C. Bast,William N. Hait, Raphael E. Pollock, and Ralph R.Weichselbaum
2 Biological hallmarks of cancer 00
Douglas Hanahan and Robert A.Weinberg
Part 2: TUMOR BIOLOGY
3 Technologies and Models to Study Cancer 00
Srinivas R. Viswanathan,David A. Tuveson, and Matthew Meyerson
4 Oncogenes 00
Marco A. Pierotti, Milo Frattini, Francesca Molinari, Gabriella Sozzi, and Carlo M. Croce
5 Tumor suppressor genes 00
David Cosgrove, Ben H. Park, and Bert Vogelstein
6 Epigenetic contributions to human cancer 00
James G. Herman and Stephen B. Baylin
7 Cancer genomics and evolution 00
William P.D. Hendricks, Aleksandar Sekulic, Alan H. Bryce, Muhammed Murtaza, Pilar Ramos, and Jeffrey M. Trent
8 Chromosomal Abberations in Human Cancer 00
David VanderWeele, Megan E. McNerney, and Michelle M. Le Beau
9 MicroRNA expression in cancer 00
Serge Patrick Nana–Sinkam, Mario Acunzo, and Carlo M. Croce
10 Aberrant signaling pathways in cancer 00
Luca Grumolato and Stuart A. Aaronson
11 Differentiation therapy 00
Sai–Juan Chen, Xiao–Jing Yan, Guang–Biao Zhou, and Zhu Chen
12 Cancer stem cells 00
Yadwinder S. Deol, Jill Granger, and Max S.Wicha
13 Cancer Cell Death 00
John C. Reed
14 Cancer cell immortality: targeting telomerase 00
Ilgen Mender, Zeliha Gunnur Dikmen,Woodring E. Wright, and Jerry W. Shay
15 Cancer metabolism 00
Natalya N. Pavlova and Craig B.Thompson
16 Modeling therapy of late or early–stage metastatic disease in mice 00
Robert S. Kerbel, Marta Paez–Ribes, Shan Man, Ping Xu, Eric Guerin,William Cruz–Munoz, and John M. L. Ebos
17 Tumor angiogenesis 00
John V. Heymach, Amado Zurita–Saavedra, Scott Kopetz, Tina Cascone, and Monique Nilsson
Part 3: QUANTITATIVE ONCOLOGY
18 Cancer bioinformatics 00
John N.Weinstein
19 Systems biology and genomics 00
Saima Hassan, Laura M. Heiser, and JoeW. Gray
20 Statistical innovations in cancer research 00
J. Jack Lee and Donald A. Berry
21 Biomarker–based clinical trial design in the era of genomic medicine 00
Richard Simon and Martine J. Piccart–Gebhart
22 Clinical informatics 00
Edward P. Ambinder
Part 4: CARCINOGENESIS
23 Chemical carcinogenesis 00
Lorne J. Hofseth, AinsleyWeston, and Curtis C. Harris
24 Endocrine and genetic bases of hormone–related cancers 00
Leslie Bernstein, Xia Pu, and Jian Gu
25 Ionizing radiation 00
David J. Grdina
26 Ultraviolet radiation carcinogenesis 00
James E. Cleaver, Susana Ortiz–Urda, Radhika Gulhar, Sarah Arron, Lionel Brookes, andDavid L. Mitchell
27 Inflammation and cancer 00
Jelena Todoric, Atsushi Umemura, Koji Taniguchi, and Michael Karin
28 RNA tumor viruses 00
Robert C. Gallo and Marvin S. Reitz
29 Herpesviruses 00
Jeffrey I. Cohen
30 Papillomaviruses and cervical neoplasia 00
Michael F. Herfs, Martin C. Chang, and Christopher P. Crum
31 Hepatitis viruses and hepatoma 00
HongyangWang
32 Parasites 00
Mervat Z. El Azzouni, and Radwa G. Diab
Part 5: EPIDEMIOLOGY, PREVENTION AND DETECTION
33 The burden of cancer worldwide: current and future perspectives 00
Jacques Ferlay, Christopher P.Wild, and Freddie Bray
34 Cancer epidemiology 00
XifengWu, Xia Pu, Stephanie C. Melkonian, and Margaret R. Spitz
35 Behavioral approaches to cancer prevention 00
Errol J. Philip and Jamie S. Ostroff
36 Diet and nutrition in the etiology and prevention of cancer 00
Steven K. Clinton, Elizabeth M. Grainger, and Edward L. Giovannucci
37 Chemoprevention of cancer 00
William N.William,Waun K. Hong, and Scott M. Lippman
38 Cancer Screening and Early Detection 00
OtisW. Brawley
Part 6: CLINICAL DISCIPLINES
39 Nexgen Pathology: Predicting clinical course and targeting disease causation 00
Carlos Cordon–Cardo and Adolfo Firpo–Betancourt
40 Molecular diagnostics in cancer 00
Roshni D. Kalachand, Bryan T. Hennessy, Robert C. Bast, and Gordon B. Mills
41 Principles of Conventional and Molecular Imaging 00
Lawrence H. Schwartz
42 Interventional Radiology for the Cancer Patient 00
Judy Ahrar, Michael J.Wallace, and Rony Avritscher
43 Principles of Surgical Oncology 00
Mark Bloomston, Donald L. Morton , Raphael E. Pollock, Michael Choti, and Ken K. Tanabe
44 Principles of radiation oncology 00
Philip P. Connell and Ralph R.Weichselbaum
45 Principles of Medical Oncology 00
William N. Hait, James F. Holland, Emil Frei III, Donald W. Kufe, Robert C. Bast Jr., andWaun KiHong
46 Palliative care 00
Cardinale B. Smith
47 Principles of psycho–oncology 00
Jimmie C. Holland and TaliaW.Wiesel
48 Principles of cancer rehabilitation medicine 00
Michael D. Stubblefield, David C. Thomas, and Kristjan T. Ragnarsson
49 Integrative oncology in cancer care 00
Gabriel Lopez, Richard Lee, Alejandro Chaoul, M. Kay Garcia, and Lorenzo Cohen
50 Health services research 00
Michaela A. Dinan, Bradford R. Hirsch, and Amy Abernethy
Part 7: INDIVIDUALIZED TREATMENT
51 Personalized Medicine in Oncology Drug Development 00
William N. Hait
Part 8: CHEMOTHERAPY
52 Preclinical and early clinical development of chemotherapeutic drugs, mechanism–based agents and biologics 00
Axel–R. Hanauske and Daniel D. Von Hoff
53 Tumor growth kinetics 00
Elizabeth Comen, Theresa A. Gilewski, and Larry Norton
54 Principles of Dose, Schedule, and Combination Chemotherapy 00
William N. Hait and Joseph P. Eder
55 Pharmacology 00
Manish R. Sharma and Mark J. Ratain
56 Folate Antagonists 00
Peter Cole and Joseph R. Bertino
57 Pyrimidine and purine antimetabolites 00
Robert B. Diasio
58 Alkylating agents and platinum antitumor compounds 00
Zahid H. Siddik
59 DNA topoisomerase targeting drugs 00
AnishThomas, Susan Bates,William D. Figg Sr, and Yves Pommier
60 Microtubule–Targeting Natural Products 00
Eric Rowinsky
61 Endocrine therapy for hormone receptor positive breast cancer 00
Aman U. Buzdar, Shaheenah Dawood, Harold A. Harvey, and V. Craig Jordan
62 Drug resistance and its clinical circumvention 00
Jeffrey A.Moscow, KennethH. Cowan, and Branimir I. Sikic
Part 9: BIOLOGICAL AND GENE THERAPY
63 Cytokines, interferons, and hematopoietic growth factors 00
Suhendan Ekmekcioglu and Elizabeth A. Grimm
64 Monoclonal serotherapy 00
Robert C. Bast, Michael R. Zalutsky, and Arthur E. Frankel
65 Vaccines and immunostimulants 00
Jeff Schlom
66 Cell–based cancer immunotherapy 00
Krina K. Patel, Judy S. Moyes, and Laurence J. Cooper
67 Cancer immunotherapy 00
Padmanee Sharma, Sumit K. Subudhi, Karl Peggs, Sangeeta Goswami, Jianjun Gao, Sergio Quezada, and James P. Allison
68 Cancer gene therapy 00
Haruko Tashiro and Malcolm Brenner
69 Cancer nanotechnology 00
Yanlan Liu, Danny Liu, Jinjun Shi, and Robert S. Langer
70 Hematopoietic cell transplantation 00
Roy Jones, Elizabeth Shpall, and Richard Champlin
Part 10: SPECIAL POPULATIONS
71 Principles of pediatric oncology 00
Teena Bhatla andWilliam L. Carroll
72 Cancer and pregnancy 00
Jennifer K. Litton
73 Cancer and aging 00
ArtiHurria,Hyman B. Muss, and Harvey J. Cohen
74 Disparities in Cancer Care 00
Otis Brawley
75 Immunoeffeciently related cancers 00
David T. Scadden and Jeremy S. Abramson
76 Cancer survivorship: new challenge in cancer medicine 00
Julia H. Rowland
Part 11: DISEASE SITES
77 Primary and metastatic neoplasms of the brain in adults 00
Lisa M. DeAngelis
78 Neoplasms of the eye 00
Jasmine H. Francis, Amy C. Schefler, and David H. Abramson
79 Neoplasms of the endocrine glands 00
Chirag D. Ghandi, Margaret Pain, and Kalmon Post
80 Neoplasms of the thyroid 00
Steven I. Sherman, Maria E. Cabanillas, and Stephen Lai
81 Neoplasms of the Adrenal Cortex 00
Tito Fojo
82 Tumors of the diffuse neuroendocrine and gastroenteropancreatic system 00
Evan Vosburgh
83 Neoplasms of the head and neck 00
Renata Ferrarotto, Merrill S. Kies, Adam S. Garden, and Michael E. Kupferman
84 Cancer of the Lung 00
Charles Lu, Daniel Morgensztern, Anne Chiang, Amir Onn, Boris Sepesi, Ara A. Vaporciyan, Joe Y. Chang, Ritsuko Komaki, Ignacio I. Wistuba, and Roy S. Herbst
85 Malignant pleural mesothelioma 00
Daniel R. Gomez, Anne S. Tsao, Haining Yang, and Harvey I. Pass
86 Thymomas andThymic Tumors 00
Alberto Marchevsky and Ronan Kelly
87 Tumors of the heart and great vessels 00
Anthony F. Yu, Sai–Ching J. Yeung, Carmen P. Escalante, Sarina van der Zee, A. P. Chahinian, and Valentin Fuster
88 Primary germ cell tumors of the thorax 00
John D. Hainsworth and F. Anthony Greco
89 Neoplasms of the Esophagus 00
MaxW. Sung, Virginia R. Litle, Steven J. Chmura, Stephen G. Swisher, David C. Rice, Jaffer A. Ajani, Ritsuko K. Komaki, andMark K. Ferguson
90 Carcinoma of the Stomach 00
Carl Schmidt, Mariela Blum Murphy, James C. Yao, and Christopher Crane
91 Primary neoplasms of the liver 00
Junichi Shindoh, KristofferW. Brudvik, and Jean–Nicolas Vauthey
92 Gallbladder and Bile Duct Cancer 00
Ahmed O. Kaseb, Melanie B. Thomas, Steven A. Curley
93 Neoplasms of the Exocrine Pancreas 00
Robert A.Wolff, Christopher H. Crane, Donghui Li, Douglas B. Evans, AnirbanMaitra, and Susan Tsai
94 Neoplasms of the colon, small intestine, vermiform appendix and peritoneum 00
Doug Tyler and Georgia Beasley
95 Neoplasms of the anus 00
Bruce D. Minsky and Jose G. Guillem
96 Renal cell carcinoma 00
Earle F. Burgess, Stephen B. Riggs, Brian I. Rini, and Derek Raghavan
97 Urothelial Cancer 00
Derek Raghavan, Richard Cote, Earle F. Burgess, Stephen B. Riggs, and Michael Haake
98 Neoplasms of the Prostate 00
Christopher J. Logothetis, Jeri Kim, JohnW. Davis, Brian F. Chapin, Deborah Kuban, Eleni Efstathiou, and Ana Aparicio
99 Tumors of the penis and urethra 00
Raymond Lance and Michael B.Williams
100 Testis cancer 00
Craig Nichols, Lawrence Einhorn, and Christian Kollmannsberger
101 Cancer of the vulva and vagina 00
Jacob Rotmensch and Summer Dewdney
102 Neoplasms of the cervix 00
Anuja Jhingran
103 Endometrial cancer 00
Jamal Rahaman, Karen Lu, and Carmel J. Cohen
104 Epithelial ovarian, fallopian tube, and peritoneal cancer 00
Jonathan S. Berek, Michael L. Friedlander, Robert C. Bast Jr.
105 Nonepithelial Ovarian Malignancies 00
Jonathan S. Berek, Michael L. Friedlander, and Robert C. Bast
106 Molar pregnancy and gestational trophoblastic neoplasia 00
Donald P. Goldstein, Ross S. Berkowitz, and Neil S. Horowitz
107 Gynecologic sarcomas 00
Jamal Rahaman and Carmel J. Cohen
108 Neoplasms of the Breast 00
Hope Rugo
109 Malignant Melanoma 00
Kim Margolin, Vernon Sondak, Susan Swetter, Scott Woodman, Jonathan Zager and Justin Ko
110 Other skin cancers 00
William G. Stebbins, Eric A. Millican, and Victor A. Neel
111 Bone Tumors 00
Tim Damron
112 Soft Tissue Sarcomas 00
Robert G. Maki, Chandrajit P. Raut, and Brian OffkSullivan
113 The Myelodyplastic Syndrome 00
Lewis R. Silverman
114 Acute Myeloid Leukemia in Adults: Mast Cell Leukemia and Other Mast Cell Neoplasms 00
Charles A. Schiffer and Richard Stone
115 Chronic myeloid leukemia 00
Jorge Cortes, Richard T. Silver, and Hagop M. Kantarjian
116 Acute lymphoblastic leukemia 00
Nitin Jain, Stefan Faderl, Hagop Kantarjian, and Susan O Brien
117 Chronic Lymphocytic Leukemia and Hairy Cell Leukemia 00
Kanti R. Rai and Jacquie Barrientos
118 Hodgkin lymphoma 00
Carol S. Portlock, Anita Kumar, and James Armitage
119 Non–Hodgkin Lymphoma 00
Arnold S. Freedman and Ann S. LaCasce
120 Mycosis fungoides and Sèzary syndrome 00
Richard T. Hoppe, Youn H. Kim, and Ranjana H. Advani
121 Plasma Cell Tumors 00
Kenneth C. Anderson
122 Myeloproliferative Neoplasms: Essential Thrombocythemia, Primary Myelofibrosis and Polycythemia Vera 00
AyalewTefferi
123 Neoplasms of Unknown Primary Site 00
John D. Hainsworth and F. Anthony Greco
Part 12: MANAGEMENT OF CANCER COMPLICATIONS
124 Anorexia and cachexia 00
Takao Ohnuma
125 Antiemetic Therapy 00
Patrick M. Forde, David S. Ettinger
126 Neurologic complications of cancer 00
Lisa M. DeAngelis
127 Dermatologic Complications of Cancer Chemotherapy 00
Anisha B. Patel and Madeleine M. Duvic
128 Skeletal complications 00
Michael A. Via, Ilya Iofin, and Jeffrey I. Mechanick
129 Hematologic complications and blood bank support 00
Richard M. Kaufman and Kenneth C. Anderson
130 Coagulopathic complications of cancer patients 00
Maria T. De Sancho and Jacob H. Randa
131 Urologic complications 00
Rachel A. Sanford, Ala Abudayyeh, Christopher J. Logothetis, andNizar M. Tannir
132 Cardiac Complications 00
Michael S. Ewer
133 Respiratory Complications 00
Vickie R. Shannon, George A. Eapen, Carlos A. Jimenez, Rodolfo C. Morice, Elizabeth L. Travis, Lara Bashoura, Scott E. Evans, Roberto Adachi, Saadia A. Faiz, Diwakar
D. Balachandran, S. Egbert Pravinkumar, Burton F. Dickey, Horiana B. Grosu, andMichaelH. Kroll
134 Gastrointestinal and hepatic complications in cancer patients 00
Robert S. Bresalier, H. Franklin Herlong, and Boris Blechacz
135 Oral complications of cancer and their treatment 00
Stephen T. Sonis and Anna Yuan
136 Gonadal complications 00
Vignesh Narayanan and Catherine E. Klein
137 Sexual dysfunction 00
Leslie R. Schover
138 Endocrine complications and paraneoplastic syndromes 00
S. JimYeung and Robert F. Gagel
139 Infections in patients with cancer 00
Lior Nesher and Kenneth V.I. Rolston
140 Oncologic emergencies 00
Sai–Ching Jim Yeung and Carmen P. Escalante
Part 13: THE FUTURE OF ONCOLOGY
141 A vision for 21st century healthcare 00
Leroy Hood, Kristin Brogaard, and Nathan D. Price

Notă biografică

Robert C. Bast Jr, MD, Vice President for Translational Research, MD Anderson Cancer Center, Houston, TX, USA  
Carlo M. Croce, MD, Distinguished University Professor, The John W. Wolfe Chair in Human Cancer Genetics, Professor and Chair, Department of Molecular Virology, Immunology and Medical Genetics, The Wexner Medical Center, The Ohio State University, Columbus, OH, USA  
William Hait, MD, PhD, Global Head research and Development, Janssen pharmaceutical companies of Johnson and Johnson, NJ, USA  
Waun Ki Hong, MD, DMSc, Professor of Thoracic/Head and Neck Medical Oncology, American Cancer Society Professor, Samsung Distinguished University Chair in Cancer Medicine Emeritus, The University of Texas M.D.Anderson Cancer Center, Houston, TX, USA                                                     
Donald W. Kufe, MD, Distinguished Physician, Dana–Farber Cancer Institute, Professor of Medicine
Harvard Medical School, Leader, Translational Pharmacology and Early Therapeutic Trials Program
Dana–Farber/Harvard Cancer Center, Boston, MA, USA  
Martine Piccart–Gebhart MD PhD, Professor of Oncology, Université Libre de Bruxelles (ULB), Head of the Medicine Department, Jules Bordet Institute, Brussels, Belgium
Raphael E. Pollock, MD, PhD, FACS, Professor and Director, Division of Surgical Oncology, Surgeon in Chief, James Comprehensive Cancer Center, Surgeon in Chief, The Ohio State University Health System, The Ohio State University Wexner Medical Center, Columbus, OH, USA
Ralph R. Weichselbaum, MD, Daniel K. Ludwig Professor Chair Dept of Radiology and Cellular Oncology University of Chicago Hospital Director Chicago Tumor Institute, IL, USA  
Dr Hongyang Wang, Professor and Director, National Center for Liver Cancer, China; and Eastern Hepatobiliary Surgery Hospital, Shanghai, China 
James F. Holland, MD, ScD (hc), Distinguished Professor of Neoplastic Diseases, Director Emeritus of Derald H.Rutttenberg Cancer Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA

ASSOCIATE EDITOR

Fadlo R. Khuri, MD, Executive Associate Dean for Research, Emory University School of Medicine, Atlanta, GA, USA; President, the American University of Beirut, Beirut, Lebanon