Histopathology of Nodal and Extranodal Non-Hodgkin’s Lymphomas

De (autor) M. Paulli De (autor) A. Le Tourneau
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en Limba Engleză Carte Hardback – 20 Nov 2003
During the 10 years since the last edition of Histopathology of Non-Hodgkin's Lymphomas, based on the updated Kiel classification, our knowledge on malignant lymphomas, especially on extranodal lymphomas, has increased. This volume - Histopathology of Nodal and Extranodal Non-Hodgkin's Lymphomas - is an expanded and completely revised edition, now based on the WHO classification. The parallels to the updated Kiel classification and the REAL classification are indicated. The information is organized in organ-specific chapters, comprising the well-known nodal lymphoma entities as well as all known extranodal lymphomas and the different organ-specific clinico-pathological entities: lymphomas of the spleen, the gastrointestinal tract, the skin, etc. In addition to the morphology, the major immunohistochemical, molecular genetic, and clinical data are included in each chapter.
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ISBN-13: 9783540638018
ISBN-10: 3540638016
Pagini: 444
Dimensiuni: 178 x 254 x 33 mm
Greutate: 1.25 kg
Ediția: 3rd completely rev. and updated ed. 2004
Editura: Springer
Colecția Springer
Locul publicării: Berlin, Heidelberg, Germany

Public țintă



1 History of Lymphoma Classification.- 1.1 Introduction.- 1.2 The Kiel Classification.- 1.3 The REAL Classification Proposal.- 1.4 The WHO Classification.- References.- 2 Current Status of Lymphoma Classification.- 2.1 Introduction.- 2.2 Small- and Large-Cell Versus Low- and High-Grade.- 2.3 Primary Versus Secondary Lymphoma.- 2.4 Definition of Immunocytoma and Its Border with Marginal Zone B-Cell Lymphoma.- 2.5 Indistinct Border Between Nodal Marginal Zone B-Cell Lymphoma and Follicular Lymphoma with Marginal Zone Differentiation.- 2.6 Grading of Follicular Lymphoma.- 2.7 Distinction Between Diffuse Large B-Cell Lymphoma and Burkit’s Lymphoma: Reproducibility and Value of Subclassification.- 2.8 Problems in Reproducibly Recognizing Anaplastic Large-Cell Lymphoma and Lymphoblastic Lymphoma on Purely Morphological Grounds.- 2.9 Is Peripheral T-Cell Lymphoma, Unspecified a Distinct Clinicopathological Entity or a Catchall Term?.- 2.10 Neither the WHO nor the EORTC Classification of Cutaneous Lymphoma Covers Today’s Knowledge.- References.- 3 Epidemiology.- 3.1 Introduction.- 3.2 Statistical Data of the Kiel Lymphoma Registry.- 3.2.1 Age and Sex Distribution.- Malignant Lymphoma of Childhood.- References.- 4 Nodal B-Cell Lymphoma.- 4.1 Precursor B-Cell Lymphoblastic Leukemia.- 4.2 Peripheral B-Cell Lymphoma.- 4.2.1 Small-B-Cell Lymphoma.- Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma.- Lymphoplasmacytic Lymphoma — Partially Corresponding to Macroglobulinemia Waldenström.- Hairy Cell Leukemia.- Plasmacytoma.- Nodal Marginal Zone B-Cell Lymphoma.- Follicular Lymphoma.- Mantle Cell Lymphoma.- 4.2.2 Large-B-Cell Lymphoma.- Diffuse Large-B-Cell Lymphoma — Common Features.- Diffuse Large-B-Cell Lymphoma — Morphological Variants.- Diffuse Large-B-Cell Lymphoma — Clinical Variants.- 4.2.3 Burkitt’s Lymphoma.- References.- 5 Nodal and Leukemic NK/T-Cell Lymphoma.- 5.1 Precursor T-Lymphoblastic Leukemia/Lymphoma.- 5.2 Peripheral NK/T-Cell Lymphoma.- 5.2.1 Peripheral NK/T-Cell Lymphoma — Predominately Leukemic.- T-Cell Chronic Lymphocytic/Prolymphocytic Leukemia.- Adult T-Cell Leukemia/Lymphoma.- 5.2.2 Peripheral NK/T-Cell Lymphoma Predominately Nodal.- Angioimmunoblastic T-Cell Lymphoma.- Peripheral T-Cell Lymphoma, Unspecified.- Mycosis Fungoides/Sézary’s Syndrome Secondary to the Lymph Node.- Anaplastic Large-Cell Lymphoma (T and Null Types).- References.- 6 Extranodal Lymphoma.- 6.1 Introduction.- 6.2 Gastrointestinal Lymphoma.- 6.2.1 B-Cell Lymphoma.- Extranodal Marginal Zone B-Cell Lymphoma of MALT.- Intestinal Follicular Lymphoma.- Multiple Lymphomatous Polyposis — Intestinal Mantle Cell Lymphoma.- Diffuse-Large-B-Cell Lymphoma of Gastrointestinal Tract.- Burkitt’s Lymphoma of the Gastrointestinal Tract.- 6.2.2 Primary Gastrointestinal T-Cell Lymphoma.- Enteropathy-Type T-Cell Lymphoma.- NK/T-Cell Lymphoma, Nasal Type.- Anaplastic Large-Cell Lymphoma.- 6.3 Lymphoma of the Upper Aerodigestive Tract.- 6.3.1 Lymphoma of the Oral Cavity.- 6.3.2 Lymphoma of Waldeyer’s Ring and the Pharynx.- 6.3.3 Lymphoma of the Nasal Cavity and Paranasal Sinuses.- B-Cell Lymphoma.- Extranodal NK/T-Cell Lymphoma — Nasal Type.- 6.3.4 Lymphoma of the Larynx and Trachea.- 6.4 Malignant Lymphoma of the Major Salivary Glands.- 6.5 Lymphoma of the Eye, Lachrymal Glands, and Orbit.- 6.5.1 Lymphoma of the Conjunctiva, Eyelids, Lachrymal Glands, and Orbit.- 6.5.2 Lymphoma of the Uvea and Retina (Similar to CNS Lymphoma).- 6.5.3 Primary Lymphoma of the Eye, Lachrymal Glands, and Orbit.- 6.6 Lymphoma of the Mediastinum.- 6.6.1 Mediastinal (Thymic) Large-B-Cell Lymphoma.- 6.6.2 Extranodal Marginal Zone B-Cell Lymphoma of the Thymus.- 6.6.3 Mediastinal Involvement in Precursor T- or B-Cell Lymphoblastic Lymphoma.- 6.6.4 Mediastinal Involvement in Small-B-Cell Lymphoma.- 6.6.5 Mediastinal Involvement in Large-B-Cell Lymphoma Other Than Primary Mediastinal Large-B-Cell Lymphoma and Burkitt’s Lymphoma.- 6.6.6 Mediastinal Involvement in NK/T-Cell Lymphoma.- 6.7 Lymphoma of the Lung.- 6.7.1 Primary Lymphoma of the Lung.- Extranodal Marginal Zone B-Cell Lymphoma of MALT.- Primary Diffuse Large-B-Cell Lymphoma of the Lung.- Primary Lung Intravascular Large-B-Cell Lymphoma.- Large B-Cell Lymphoma Secondary to Liebow’s Lymphomatoid Granulomatosis.- Primary Lung Plasmacytoma.- Primary NK/T-Cell Lymphoma of the Lung.- 6.8 Lymphoma of the Pleura.- 6.8.1 Primary Lymphoma of the Pleura.- Primary Effusion Lymphoma.- Pyothorax-Associated Primary Lymphoma.- 6.8.2 Secondary Pleural Lymphoma.- 6.9 Lymphoma of the Heart.- 6.9.1 Primary Cardiac Lymphoma.- 6.10 Splenic Lymphoma.- 6.10.1 Primary Splenic Lymphoma or Lymphoma with a Splenic Predominance.- Hairy Cell Leukemia.- Splenic Marginal Zone Lymphoma.- Primary Splenic Lymphoplasmacytic Lymphoma.- Plasmacytoma.- B-Prolymphocytic Leukemia.- Large B-Cell Lymphoma of the Spleen.- Hepatosplenic T-Cell Lymphoma.- T-Cell Large Granular Lymphocytic Leukemia.- Other Types of Lymphoma.- 6.10.2 Secondary Splenic Lymphoma.- Small-B-Cell Lymphoma.- Other Types of B-Cell Lymphoma.- Peripheral NK/T-Cell Lymphoma.- Precursor Cell Neoplasias: B- and T-Lymphoblastic Lymphoma.- 6.11 Lymphoma of the Liver.- 6.11.1 Primary Lymphoma of the Liver.- Primary Lymphoma Presenting as a Tumorous Infiltrate of the Liver.- Primary Hepatic Lymphoma Presenting as Severe Hepatic Disease.- 6.11.2 Secondary Lymphoma of the Liver.- 6.12 Lymphoma of the Breast, Reproductive, and Urinary Systems.- 6.12.1 Malignant Lymphoma of the Breast.- Primary Lymphoma of the Breast.- Secondary Lymphoma of the Breast.- 6.12.2 Malignant Lymphoma of the Uterus.- Primary Uterine Lymphoma.- Addendum: Primary Lymphoma of the Vagina.- Secondary Uterine and Vaginal Lymphoma.- 6.12.3 Malignant Lymphoma of the Ovary.- Primary Lymphoma of the Ovary.- Secondary Lymphoma of the Ovary.- 6.12.4 Lymphoma of Testis.- 6.12.5 Malignant Lymphoma of the Prostate.- 6.12.6 Lymphoma of the Kidney.- Primary Lymphoma of the Kidney.- Secondary Kidney Lymphoma.- 6.12.7 Malignant Lymphoma of the Urinary Bladder.- 6.13 Endocrine Gland Lymphoma.- 6.13.1 Malignant Lymphoma of the Thyroid Gland.- 6.13.2 Malignant Lymphoma of the Adrenal Gland.- 6.14 Cutaneous Lymphoma.- 6.14.1 Primary Cutaneous B-Cell Lymphoma.- Cutaneous Marginal Zone B-Cell Lymphoma/SALT.- Follicular Lymphoma.- Plasmacytoma.- Diffuse Large-B-Cell Lymphoma.- 6.14.2 Cutaneous T-Cell Lymphoma.- Mycosis Fungoides — Classical Type.- Sézary’s Syndrome.- Primary Cutaneous CD30+ T-Cell Lymphoproliferative Disorders.- Primary Cutaneous NK/T-Cell Lymphoma.- 6.15 Lymphoma of Soft Tissues.- 6.16 Lymphoma of the Bone.- 6.16.1 Primary Lymphoma of Bone.- 6.16.2 Secondary Bone Lymphoma.- 6.17 Lymphoma of the Central Nervous System.- 6.18 Intravascular Large-B-Cell Malignant Lymphoma.- References.- 7 Plasma Cell Proliferations.- 7.1 Plasma Cell Myeloma/Bone Marrow Plasmacytoma.- 7.1.1 Clinical Variants.- Diffuse Decalcifying Myelomatosis.- Osteosclerotic Myeloma.- Nonsecretory Myeloma.- Solitary Myeloma.- Plasma Cell Leukemia.- Variants with Peculiar Clinical Behavior.- 7.2 Extraosseous (Extramedullary) Plasmacytoma.- 7.3 Associated Diseases.- 7.3.1 Castleman’s Disease.- 7.3.2 POEMS Syndrome.- 7.3.3 Primary Amyloidosis.- 7.3.4 Light- and/or Heavy-Chain Deposition Diseases.- 7.4 Heavy-Chain Diseases.- References.- 8 Lymphoma Occurring in a Setting of Immunodeficiency.- 8.1 Lymphoproliferative Disorders Associated with Congenital Immunodeficiencies.- 8.1.1 Ataxia-Telangiectasia.- 8.1.2 Wiskott-Aldrich Syndrome.- 8.1.3 Common Variable Immunodeficiency Disorder.- 8.1.4 Severe Combined Immunodeficiency.- 8.1.5 X-linked Lymphoproliferative Disorder.- 8.1.6 Hyper-IgM Syndrome.- 8.1.7 JOB Syndrome.- 8.1.8 Nijmegen Breakage Syndrome.- 8.2 Lymphoma and Lymphoproliferative Disorders Associated with Acquired Immunodeficiency.- 8.2.1 HIV-Related Lymphoma.- 8.2.2 Post-transplant Lymphoproliferative Disorders.- Plasmacytic Hyperplasia and Infectious-Mononucleosis-like PTLD.- Polymorphic PTLD.- Monomorphic B-Cell PTLD.- Monomorphic T-Cell PTLD.- Hodgkin’s-Like PTLD.- References.- 9 Practical Guidelines for Lymphoma Diagnosis in Bone Marrow.- 9.1 Patterns of Involvement.- 9.1.1 Paratrabecular Infiltrates.- 9.1.2 Intertrabecular Infiltrates.- Interstitial Infiltrate.- Nodular Infiltrate.- Massive Infiltrate.- Monocellular Dispersion.- 9.1.3 Intrasinusoidal Infiltrate.- 9.2 Associated Lesions or Modifications.- 9.2.1 Reticulum Fibers Framework.- 9.2.2 Vascular Modifications.- 9.2.3 Reactive Changes.- Interstitial Edema.- Polyclonal Plasmacytosis.- Reactive Lymphoid Nodules.- Chronic Inflammation.- Eosinophilic Necrosis.- Modifications of the Normal Hematopoietic Cell Lines.- 9.3 Diagnosis of Bone Marrow Involvement According to the Different Types of Lymphoma.- 9.3.1 Small B-Cell Lymphoma (Kroft et al. 1995).- B-Cell Chronic Lymphocytic Leukemia.- B-Prolymphocytic Leukemia.- Lymphoplasmacytic Lymphoma.- Follicular Lymphoma.- Mantle Cell Lymphoma.- Primary Splenic and Nodal and Extranodal Marginal Zone Lymphoma.- Hairy Cell Leukemia.- Myeloma.- Differential Diagnosis.- 9.3.2 Large B-Cell Lymphoma.- T-Cell-Rich/Histiocyte-Rich Large-B-Cell Lymphoma.- Intravascular Large B-Cell Lymphoma.- 9.3.3 Burkitt’s Lymphoma.- 9.3.4 Precursor Cell Lymphoma (B- and T-Cell Lymphoblastic Lymphoma or Acute Leukemia).- 9.3.5 NK/T-Cell Lymphoma.- T-Prolymphocytic Leukemia.- T-Cell Large Granular Lymphocytic Leukemia.- Peripheral T-Cell Leukemia Lymphoma, Unspecified.- Peripheral T-Cell-Lymphoma, Angioimmunoblastic.- Anaplastic Large-Cell Lymphoma.- Hepatosplenic T-Cell Lymphoma.- General Comments.- 9.4 Differential Diagnosis.- 9.4.1 Reactive Lymphoid Nodules.- 9.4.2 Reactive Intravascular Lymphocytosis.- 9.4.3 Hodgkin’s Lymphoma.- 9.4.4 Non-lymphoid Acute Leukemia.- 9.4.5 Systemic Mastocytosis.- 9.4.6 Undifferentiated Carcinoma.- References.- 10 Practical Advice: Methods for the Diagnosis of Malignant Lymphoma.- 10.1 The Diagnosis of Malignant Lymphoma.- 10.1.1 Practical Tips.- 10.2 Immunohistochemistry and Molecular Clonality Analysis in the Diagnosis of Lymphoma.- References.


From the reviews:
"Dr. Alfred Feller and Dr. Jacques Diebold have presented us with succinct descriptions and high quality Giemsa-stained photomicrographs … . Their most valuable contribution, however, is their discussion of unresolved problems of classification … . The authors also bring attention to significant unresolved problems in the WHO classification, including thought-provoking discussions of … . are to be congratulated for a job well done and for a most enjoyable and personal approach to the complex problems of lymphomas." (Maurice P. Barcos, Oncology Intl. J. Cancer Research and Treatment, Vol. 67(5-6), 2004)
"Feller and Diebold’s book is not only based on the WHO classification of lymphoma, but also mirrors its presentation … . then follows something really good: a section specifically addressing, and indeed called, differential diagnosis. … Another good feature of this book is its inclusion of organ-specific sections, for example, lymphoma of the lung … . I liked this book. It is not simply a catalogue of lymphomatoid diseases. I think it will be practically useful." (Dr. D. Wright, ACP News, 2005)


Now including all known extra-nodal lymphomas
Includes, for the first time, details of immunohistochemistry and molecular genetics
Based on WHO classification
Featuring numerous high-quality illustrations