Hematology: Basic Principles and Practice

De (autor) , Editat de Ronald Hoffman, Edward J. Benz, Helen Heslop, Jeffrey Weitz
Notă GoodReads:
en Limba Engleză Hardback – 30 Aug 2017

Get the expert guidance you need to offer your patients the best possible outcomes with Hematology: Basic Principles and Practice, 7th Edition. This thoroughly up-to-date text contains both unparalleled scientific content and must-know clinical guidance, so you can enhance your problem-solving skills and make optimal use of the newest diagnostic techniques and therapeutic options in this fast-changing field.

New to this Edition:

  • Delivers state-of-the-art information and guidance from editors and global contributors who are at the forefront of their respective subspecialty areas.
  • Features sweeping content updates throughout, including basic science research which serves as a foundation for modern hematology, recent advances in stem cell transplantation, clinical advances in the treatment of each of the hematologic malignancies, immune checkpoint inhibitors, molecular diagnostics, transfusion medicine, and much more.
  • Includes several new chapters including Epigenetics and Epigenomics, Stem Cell Model of Hematologic Diseases, Multiple Myeloma, IND Enabling Processes for Cell-Based Therapies, and Immune Checkpoint Blockade in Hematologic Malignancies.
  • New Virtual Microscope with the ability to zoom in on high-quality digital hematopathology slides and frequent content updates accessible anywhere, any time on your favorite digital device.
  • Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices.
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ISBN-13: 9780323357623
ISBN-10: 0323357628
Pagini: 2408
Ilustrații: Approx. 1000 illustrations (1000 in full color)
Dimensiuni: 222 x 281 x 70 mm
Greutate: 5.42 kg
Ediția: 7
Editura: Elsevier


  1. Anatomy and Physiology of the Gene
  2. Epigenetics and Epigenomics
  3. Genomic Approaches to Hematology
  4. Regulation of Gene Expression, Transcription, Splicing and RNA Metabolism
  5. Protein Synthesis, Processing, and Trafficking
  6. Protein Architecture: Relationship of Form and Function
  7. Signaling Transduction and Metabolomics
  8. Pharmacogenomics and Hematologic Diseases
  9. Hematopoietic Stem Cell Biology
  10. Stem Cell Model of Hematologic Malignancies
  11. Hematopoietic Microenvironment
  12. Cell Adhesion
  13. Hematopoietic Cell Trafficking and Chemokines
  14. Interactions between Hematopoietic Stem and Progenitor Cells and the Bone Marrow: Current Biology of Stem Cell Homing and Mobilization
  15. Vascular Growth in Health and Disease
  16. Cytokine/Receptor families and signal transduction
  17. Control of Cell Division
  18. Cell Death
  19. Overview and Compartmentalization of the Immune System
  20. B-Cell Development
  21. T-Cell Immunity
  22. Natural Killer Cell Immunity
  23. Dendritic Cell Biology
  24. Complement and Immunoglobulin biology leading to clinical translation
  25. Tolerance and Autoimmunity
  26. Biology of Erythropoiesis, Erythroid Differentiation, and Maturation
  27. Granulocytopiesis and Monocytopoiesis
  28. Thrombocytopoiesis
  29. Inherited Forms of Bone Marrow Failure
  30. Aplastic Anemia
  31. Paroxysmal Nocturnal Hemoglobinuria
  32. Acquired Disorders of Unilineage Blood Cell Production
  33. Pathobiology of the Human Erythrocyte and Its Hemoglobins
  34. Approach to Anemia in the Adult and Child
  35. Pathophysiology of Iron Homeostasis
  36. Disorders of Iron Metabolism: Iron Deficiency and Overload
  37. Anemia of Chronic Diseases
  38. Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias
  39. Megaloblastic Anemias
  40. Thalassemia Syndromes
  41. Pathobiology of Sickle Cell Disease
  42. Sickle Cell Disease: Clinical Features and Management
  43. Hemoglobin Variants Associated with Hemolytic Anemia, Altered Oxygen Affinity, and Methemoglobinemias
  44. Red Blood Cell Enzymopathies
  45. Red Blood Cell Membrane Disorders
  46. Autoimmune Hemolytic Anemia
  47. Extrinsic Nonimmune Hemolytic Anemias
  48. Granulocytosis, Granulocytopenia, Monocytosis, and Monocytopenia
  49. Lymphocytosis, Lymphocytopenia, Hypergammaglobulinemia, and Hypogammaglobulinemia
  50. Disorders of Phagocyte Function
  51. Congenital Disorders of Lymphocyte Function
  52. Histiocytic Disorders
  53. Lysosomal Storage Diseases: Perspectives and Principles
  54. Infectious Mononucleosis and Other Epstein-Barr Virus-Associated Diseases
  55. Progress in the Classification of Hematopoietic and Lymphoid Neoplasms: Clinical Implications
  56. The CytoGenomic Basis of Hematological Malignancies
  57. Pharmacology and Molecular Mechanisms of Antineoplastic Agents for Hematologic Malignancies
  58. Pathobiology of Acute Myeloid Leukemia
  59. Clinical Manifestations and Treatment of Acute Myeloid Leukemia
  60. Myelodysplastic Syndromes: Biology and Treatment
  61. Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome in Adults
  62. Acute Myeloid Leukemia in Children
  63. Myelodysplastic Syndrome and Myeloproliferative Syndrome in Children
  64. Pathobiology of Acute Lymphoblastic Leukemia
  65. Clinical Manifestations and Treatment in Children of Acute Lymphoblastic Leukemia
  66. Acute Lymphocytic Leukemia in Adults
  67. Chronic Myeloid Leukemia
  68. The Polycythemias
  69. Essential Thrombocythemia
  70. Primary Myelofibrosis
  71. Eosinophilia, Eosinophil-Associated Diseases, Chronic Eosinophil Leukemia, and the Hypereosinophilic Syndromes
  72. Mast Cells and Systemic Mastocytosis
  73. The Pathologic Basis for the Classification of Non-Hodgkin and Hodgkin Lymphomas
  74. Origins of Hodgkin Disease
  75. Hodgkin Lymphoma: Clinical Manifestations, Staging, and Therapy
  76. Origins of Non-Hodgkin Lymphomas
  77. Chronic Lymphocytic Leukemia
  78. Hairy Cell Leukemia
  79. Clinical Manifestations and Treatment of Indolent Lymphomas: Marginal Zone Lymphomas (Extranodal/Malt, Splenic, and Nodal)
  80. Clinical Manifestations, Staging, and Treatment of Follicular Lymphoma
  81. Mantle Cell Lymphoma
  82. Diagnosis and Treatment of Diffuse Large B-Cell Lymphoma (DLBCL) and Burkitt Lymphoma (BL)
  83. Viral-Related Lymphomas
  84. Malignant Lymphomas in Childhood
  85. T-Cell Lymphomas
  86. Multiple Myeloma
  87. Waldenstrom Macroglobulinemia/Lymphoplasmacytic Lymphoma
  88. Immunoglobuin Light-Chain Amyloidosis (Primary Amyloidosis)
  89. Clinical Approach to Infections in the Compromised Host
  90. Psychosocial Aspects of Hematologic Disorders
  91. Pain Management and Antiemetic Therapy in Hematologic Disorders
  92. Palliative Care
  93. Late Complications of Hematologic Diseases and Their Therapies
  94. Overview and Historical Perspective of Current Cell-Based Therapies
  95. Practical Aspects of Hematologic Stem Cell Harvesting and Mobilization
  96. IND Enabling Processes for Cell-Based Therapies
  97. Graft Engineering and Cell Processing
  98. Principles of Cell-Based Genetic Therapies
  99. Mesenchymal Stromal Cells
  100. T Cell Therapy of Hematological Diseases
  101. NK Cell-Based Therapies
  102. Immune Checkpoint Blockade in Hematologic Malignancies
  103. Overview and Choice of Donor of Hematopoietic Stem Cell Transplantation
  104. Indications and Outcomes of Allogeneic Hematopoietic Cell Transplantation for Hematologic Malignancies in Adults
  105. Unrelated Donor Hematopoietic Cell Transplantation
  106. Haploidentical Hematopoietic Cell Transplantation
  107. Unrelated Donor Cord Blood Transplantation for Hematologic Malignancies
  108. Graft-versus-Host Disease and Graft-versus-Leukemia Responses: Biology and Therapy
  109. Complications after Hematopoietic Cell Transplantation
  110. Human Blood Group Antigens and Antibodies
  111. Principles of Red Blood Cell Transfusion
  112. Clinical Considerations in Platelet Transfusion Therapy
  113. Human Leukocyte Antigen and Human Neutrophil Antigen Systems
  114. Principles of Neutrophil (Granulocyte) Transfusions
  115. Transfusion of Plasma Derivatives: Plasma, Cryoprecipitate, Albumin, and Immunoglobulins
  116. Preparation of Plasma-Derived and Recombinant Human Plasma Proteins
  117. Transfusion Therapy for Coagulation Factor Deficiencies
  118. Hemapheresis
  119. Transfusion Reactions to Blood and Cell Therapy Products
  120. Transfusion-Transmitted Diseases
  121. Pediatric Transfusion Medicine
  122. Overview of Hemostasis and Thrombosis
  123. The Blood Vessel Wall
  124. Megakaryocyte and Platelet Structure
  125. Molecular Basis of Platelet Function
  126. Molecular Basis of Blood Coagulation
  127. Regulatory Mechanisms in Hemostasis
  128. Clinical Approach to the Patient with Bleeding or Bruising
  129. Laboratory Evaluation of Hemostatic and Thrombotic Disorders
  130. Acquired Disorders of Platelet Function
  131. Diseases of Platelet Number: Immune Thrombocytopenia, Neonatal Alloimmune Thrombocytopenia, and Posttransfusion Purpura
  132. Thrombocytopenia Caused by Platelet Destruction, Hypersplenism, or Hemodilution
  133. Heparin-Induced Thrombocytopenia
  134. Thrombotic Thrombocytopenic Purpura and the Hemolytic Uremic Syndromes
  135. Hemophilia A and B
  136. Inhibitors in Hemophilia A and B
  137. Rare Coagulation Factor Deficiencies
  138. Structure, Biology, and Genetics of Von Willebrand Factor
  139. Disseminated Intravascular Coagulation
  140. Hypercoagulable States
  141. The Antiphospholipid Syndrome
  142. Venous Thromboembolism
  143. Mechanical Interventions in Arterial and Venous Thrombosis
  144. Atherothrombosis
  145. Stroke
  146. Acute Coronary Syndromes
  147. Atrial Fibrillation
  148. Peripheral Artery Disease
  149. Antithrombotic Drugs
  150. Disorders of Coagulation in the Neonate
  151. Hematologic Changes of Pregnancy
  152. Hematologic Manifestations of Childhood Illness
  153. Hematologic Manifestations of Systemic Disease: Liver Disease
  154. Hematologic Manifestations of Systemic Disease: Renal Disease
  155. Hematologic Manifestations of Cancer
  156. Integrated Therapies in Patients with Hematologic Diseases
  157. Hematologic Manifestations of AIDS
  158. Hematologic Manifestations of Parasitic Diseases
  159. Hematologic Problems in the Surgical Patient: Bleeding and Thrombosis
  160. The Spleen and Its Disorders
  161. Hematology in Aging

Resources for the Hematologist: Interpretive Comments and Selected Reference Values for Neonatal, Pediatric, and Adult Populations