Growth Factors and Epilepsy

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en Limba Engleză Carte Hardback – 08 Apr 2005
The discovery that a variety of growth factors modulate excitability in the adult brain, and that the expression of growth factors and their receptors are often modulated by seizure activity, has opened an exciting new chapter in epilepsy research. Recent findings shed new light on these and other ways growth factor neurobiology impacts epilepsy research, including the role of growth factors in seizure-induced neurogenesis, kindling, and morphological changes that contribute to the epileptic phenotype. In addition to neurotrophins such as brain-derived neurotrophic factor, and the p75 and trk receptors for neurotrophins, recent studies also implicate vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and glial cell line-derived neurotrophic factor (GDNF) in seizure-induced structural and functional changes. The current volume highlights seminal contributions to this field by renowned scientists in both the growth factor and epilepsy research fields.
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ISBN-13: 9781594544217
ISBN-10: 1594544212
Pagini: 237
Ilustrații: b/w illus
Dimensiuni: 189 x 262 x 32 mm
Greutate: 0.68 kg
Editura: Nova Science Publishers Inc


Preface; Seizure-induced neurogenesis in the dentate gyrus and its dependence on growth factors and cytokines; Neurotrophins, kindling, and kindling-induced morphological changes in the brain; Multiple actions of brain-derived neurotrophic factor on central neurons; Accumulation of BDNF in the dendrites: a link with epileptogenesis?; Seizure and the p75 neurotrophin receptor: death by design?; Immunohistochemical analysis of trk receptor activation in epilepsy; VEGF as a novel seizure therapeutic: killing two birds with one stone; Fibroblast growth factors and seizure-induced neuroprotection; The GDNF family of neurotrophic factors and epilepsy; Running away from epilepsy: exerciseregulated gene expression; Index.