Females Are Mosaics: X Inactivation and Sex Differences in Disease

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en Limba Engleză Carte Hardback – 05 Dec 2013
Women can be described as genetic mosaics because they have two distinctly different types of cells throughout their bodies. Unlike males, who have one X chromosome, females have two X chromosomes in every cell. Much has been written about the Y chromosome and its role in inducing maleness. This is the only book about the X chromosome as a key to female development and the role of X-related factors in the etiology of sex differences in human disease. This new editionreflects research advances from the six years since the widely praised first edition. New advances include knowledge of species differences in mammalian X inactivation processes and silencing of the inactive X chromosome.
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ISBN-13: 9780199927531
ISBN-10: 0199927537
Pagini: 328
Dimensiuni: 163 x 238 x 23 mm
Greutate: 0.62 kg
Ediția: Revised
Editura: Oxford University Press
Colecția OUP USA
Locul publicării: New York, United States

Notă biografică

Barbara Migeon, MD, has held fellowships in pediatrics, endocrinology and genetics. She is board certified in pediatrics, biochemical genetics and cytogenetics. She was the founding director of the Hopkins PhD Program in Human Genetics. Her research has been focused on the molecular mechanisms of X inactivation in human cell and the clinical consequences of the single active X chromosome.