Epigenetic Regulation in the Nervous System: Basic Mechanisms and Clinical Impact

Editat de J. David Sweatt, Michael J. Meaney, Eric J. Nestler, Schahram Akbarian
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en Limba Engleză Hardback – 27 Feb 2013

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PROSE (2013)
Epigenetic Regulation in the Nervous System addresses current understanding of the roles of epigenetic processes at the molecular/cellular level, their impact on neural development and behavior, and the potential roles of these mechanisms in neurological and psychiatric disorders. This award-winning volume spans molecular epigenetics, development, cellular physiology and biochemistry, synaptic and neural plasticity, and behavioral models, and is unique in covering epigenetically based disorders of the central nervous system.
Behavioral epigenetics is the study of how environmental factors alter behavior, addressing the fundamental mechanisms that shape development and individual vulnerability/resilience to adverse behavioral outcomes. By understanding the molecular mechanisms involved in epigenetic modulation, researchers may be able to develop targeted therapies for those individuals in whom it malfunctions.
Edited by the most highly regarded leaders in the field, this book offers a comprehensive review of behavioral epigenetics and a balanced treatment of the strengths and weaknesses in experimentation in this area. Covering background material as well as topics of current interest, it serves both as a cutting-edge resource and a foundational reference. The book will benefit neuroscience researchers and graduate students with an interest in the links between gene regulation and behavior, as will clinicians dealing with disorders such as addiction, depression, and schizophrenia.

  • BMA Medical Book Awards 2014 - Highly Commended,  Neurology, British Medical Association
  • BMA Medical Book Awards 2014 - First Prize, Neurology, British Medical Association
  • 2013 PROSE Award winner for Best in Reference Works and Best Single Volume Reference in Science from the Association of American Publishers
  • Presents a unified view of epigenetic mechanisms from behavior to genes and everything in between
  • Discusses clinically relevant disorders in the context of epigenetics research, making the volume appealing to clinicians as well as basic scientists
  • Provides numerous practical examples for the new investigator to facilitate implementation of research in neuroepigenetics
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ISBN-13: 9780123914941
ISBN-10: 0123914949
Pagini: 374
Dimensiuni: 191 x 235 x 23 mm
Greutate: 0.98 kg

Public țintă

Researchers and advanced students in molecular/cellular, developmental and behavioral neuroscience; clinical neuroscientists; research psychiatrists and psychologists


1. An Overview of the Molecular Basis of Epigenetics J. David Sweatt, Michael J. Meaney, Eric J. Nestler, and Schahram Akbarian
2. Histone modifications in the nervous system and neuropsychiatric disorders Morgan Bridi and Edwin "Ted" Abel
3. Active DNA Demethylation and 5-Hydroxymethylcytosine Junjie U. Guo, Guo-li Ming and Hongjun Song
4. Maternal Behavior Tie Yuan Zhang, Christian Caldji, Josie C. Diorio, Sabine Dhir, Gustavo Turecki, and Michael J. Meaney
5. Epigenetic Mechanisms in Learning and Memory Jeremy J. Day and J. David Sweatt
6. Drug Addiction and Reward Alfred J. Robison, Jian Feng, and Eric J. Nestler
7. The Mind and its Nucleosomes – Chromatin (dys)regulation in Major Psychiatric Disease Rahul Bharadwaj,  Cyril J. Peter, and Schahram Akbarian
8. HDAC inhibitors as novel therapeutics in Aging, and Alzheimer's disease Alexi Nott, Daniel M. Fass, Stephen J. Haggarty, and Li-Huei Tsai
9. Cell Differentiation in the CNS, Neuronal Fate Determination, and Development Yi Eve Sun
10. Imprinting in the CNS and Neurodevelopmental Disorders Weston T. Powell and Janine LaSalle
11. Neuronal Genomic and Epigenetic Diversity Michael J. McConnell and Fred H. Gage
12. Adult Neurogenesis Jenny Hsieh, Hongjun Song
13. Transgenerational Inheritance in Mammals Isabelle M. Mansuy, Rahia Mashoodh and Francis A. Champagne
14. Open Questions and Future Approaches in Neuroepigenetics J. David Sweatt, Michael J. Meaney, Eric J. Nestler, and Schahram Akbarian


"The book is primarily intended for advanced undergraduates, graduate students, active researchers and physician-scientists newly interested in the emerging field….Sweatt is also responsible for the book’s extensive illustrations, which are copies of his paintings depicting the role of epigenetic processes in the brain, and relate to work under way in his lab."--UAB News online, February 25, 2013 "Sweatt, Meaney, Nestler, and Akbarian present the first foundational work to address molecular, cellular, behavioral, and clinical roles for epigenetic mechanisms in the nervous system…This unique book is targeted for physicians and scientists, as well as researchers and students."--Reference & Research Book News, October 2013