In this issue of Gastrointestinal Endoscopy Clinics of North America, guest editors Drs. Roy Soetikno, Tonya Kaltenbach, and Hasan Maulahela bring their considerable expertise to the topic of Endoscopy Training Based on the Science of Expertise. In recent years, critical elements have been identified for advanced endoscopy training: the importance of integrating principles from expertise and education science in order to enhance efficiency and effectiveness in procedural performance, and a need to modernize endoscopy training programs to ensure practitioners are well-equipped to deliver high-quality patient care. In this issue, top experts provide a primer on providing state-of-the-art training in endoscopy, with the goal of improving patient outcomes.