This issue of Neurologic Clinics, edited by Dr. John Ringman, will cover a wider variety of topics and the latest updated on Demantia. Topics covered in this issue include, but are not limited to Updates on the basic science of AD; The role of neuropsychology in the assessment of the cognitively impaired elderly; Assessment of the Spanish-speaking cognitively impaired elderly; Early-Onset Alzheimer's disease; Vascular dementia and vascular contributions to Alzheimer's disease; Frontotemporal Degenerations; and Current and Experimental Treatments, among others.