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Clinical Chemistry Research

Editat de Brian H Mitchem, Charles L Sharnham
en Limba Engleză Hardback – 3 ian 2009
Among many research topics, this book considers phytoestrogens, natural compounds found in plants that possess oestrogen-like activity. Despite the growing evidence of the health benefits of phytoestrogens, further investigation is needed to better understand their mechanism of actions, the biological outcomes and possible adverse effects. This book chapter summarises the most recent developments of lanthanide nanorods in the field of biomedical nanotechnology. The cellular uptake of nanoparticles as a function of several parameters, such as polymeric material and surfactant type are considered. Camptothecins (CPTs) are regarded as one of the most promising anticancer drugs of the twenty-first century. A further chapter describes SAR, QSAR, and the clinical chemistry of CPT derivatives to understand their chemical-biological interactions and side effects. This book addresses the biological and pharmacological significances of identification and analysis of effective components of natural medicines and describes methods and procedures for identification and analysis. Potential future prospects in the field are provided. The porphyrazines are an emerging class of compounds exhibiting tremendous potential for use as anti-tumour therapeutic agents and in imaging applications. This book reviews the initial structure-function studies that have been carried out to date on this little-studied class of compounds. A further study hypothesises that the differences in the biology of breast cancers observed in women of different races are partially related to differences in the secretory activity of adipocytes in the breast tissue. The possible role of adipokines in breast malignancies of women of various races is reviewed.
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Specificații

ISBN-13: 9781606925171
ISBN-10: 1606925172
Pagini: 376
Ilustrații: colour photos, tables & charts
Dimensiuni: 180 x 259 x 28 mm
Greutate: 0.91 kg
Editura: Nova Science Publishers, Inc
Colecția Nova Science Publishers, Inc (US)

Cuprins

Preface; Phytoestrogens: Biochemical Aspects and Biological Activities (Q)SAR and Clinical Chemistry of Camptothecin Analogues; Application of Lanthanide (Ln= Eu & Tb) Nanoparticles in Biology and Medicine; Identification and Analysis of Effective Components in Animal Biofluids following Administration of Natural Medicines; Frontiers of Molecular Technologies in Noninvasive Prenatal Diagnosis; Polymeric Nanoparticles as Carrier Systems: How does the Material and Surface Charge Affect Cellular Uptake?; The Role of 1, 25 Dihydroxy-Vitamin D3 in Immunity to Infectious Disease; Generation and Analysis of Disease-Specific Mouse Models by Clinical Chemical Screening; Gene Therapy of Congenital Disease: Applications, Problems and Prospects; Porphyrazine Anti-Tumor Agents; Mass Spectrometry in Clinical Chemistry; Quantitative Proteome-Disease Relationships (QPDRs) in Clinical Chemistry: Prediction of Prostate Cancer with Spectral Moments of PSA/MS Star Networks; "Not So Innocent" - Adipocytes May Explain Racial Differences in Breast Cancer: Implications for Clinical Chemistry; Analytical Method of Allantoin Detection in Human Sera and the Clinical Significance of this Measurement; Relationship between Creatine Kinase Activity and Serum Aminotransferase Activity in Patients with Extensive Rhabdomyolysis, Myocardial Infarction, Heart, Liver; Index.