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Chromosomal Instability in Cancer Cells: Recent Results in Cancer Research, cartea 200

Editat de B. Michael Ghadimi, Thomas Ried
en Limba Engleză Hardback – 25 sep 2015
This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.
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Specificații

ISBN-13: 9783319202907
ISBN-10: 3319202901
Pagini: 350
Ilustrații: VII, 224 p. 39 illus. in color.
Dimensiuni: 155 x 235 x 20 mm
Greutate: 0.5 kg
Ediția:1st ed. 2015
Editura: Springer International Publishing
Colecția Springer
Seria Recent Results in Cancer Research

Locul publicării:Cham, Switzerland

Public țintă

Research

Cuprins

DNA Repair and Chromosomal Translocations.- CINcere modelling: What have mouse models for chromosome instability taught us?.- Telomere Dysfunction, Chromosomal Instability and Cancer.- Genetic Instability and Disease Prognostication.- Causes of Chromosomal Instability.- Patterns of Chromosomal Aberrations in Solid Tumors.- Yeast as Models of Mitotic Fidelity.- The diverse effects of complex chromosome rearrangements and chromothripsis in cancer development.- Consequences of aneuploidy in cancer: transcriptome and beyond.


Textul de pe ultima copertă

This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.


Caracteristici

Reviews up-to-date knowledge of chromosomal instability in cancer
Examines strategies to harness this information for the better treatment of cancer patients
Written by acknowledged experts in the field

Descriere

This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.